herpes Flashcards

1
Q

HSV1, hsv2 and vzv target cell

A

mucoepithelial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ebv target cell

A

epithelial cell and b lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

cmv target cell

A

epithelial cells, monocytes, lymphocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

hsv1, hsv2, hsv3 latency

A

sensory nerve ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ebv latency

A

b lymphocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

cmv latency

A

monocyte, lymphocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how long is a herpes infection? and why?

A

life long because the primary infection is followed by latent infection and recurrences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

t or f the herp can be shed assymptomatically

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

t or f reccurent cases are a source of contagion

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

t or f you hay have the herp but never develop signs or symptoms

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the current most common cause of genital herp

A

hsv 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

herp incubation period

A

1 to 26 days
-average 6-8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

how does herp manifest the majority of the time

A

it doesn’t, the herp is silent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

S+S of the herp when it happens are dependent on what?

A

the anatomical site, the age and immune status

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

the first episode is typically worse and involves the following symptoms:

A

-systemic signs and symptoms
-mucosal and extramucosal sites
-longer duration of symptoms
-longer duration of virus isolation from lessions
-higher rate of complications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what will be the site of the outbreak

A

the site of contact

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

gingiovostomatitis and pharyngitis are the most common herp in

A

kids and young adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

where are the painful vesicles/ small blisters in gingivostomatitis and pharyngitis

A

-hard and soft palate, gingiva, tongue, lip and facial areas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

other signs and symp of gingiovostomatitis and pharyngitis

A

fever, malaise, myalgias, not eating, irritable, cervical adenopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

how to swab the lesion?

A

lift it and swab the base of the lesion to send for testing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

when is a reactivation more likley?

A

when immunocomp or stressed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

drugs that treat the herp

A

acyclovir and valocyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

asymptomatic virus excretion in saliva, development of intraoral mucosal ulcerations, herpetic ulcerations on the vermilion border of the lip or facial skin (cold sore) are??

A

S+S of reactivation
*typically not a systemic thing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

when is recurrence more common

A

within the first year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

what do some people take in the first year

A

acyclovir as prophylaxis to suppress the virus more

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

what will preceed the blisters

A

symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

S+S of genital herp

A

-fever, headache, malaise, myalgias, pain, itch, discharge, tender lymphadenopathy, lesions (vesicles, pustules or ulcers) and proctitis

28
Q

what is proctitis

A

anorectal pain, discharge and tenesmus

29
Q

t or f reccurence is more localized

A

true

30
Q

what is a comon prodrome of genital herp

A

burning or tingling

31
Q

t or f affected ppl with the genital herp can shed the virus asymptomatically?

A

true

32
Q

what is herpes whitlow

A

herp on fingers
*common in dentists

33
Q

how can we diagnose hs1 and 2

A

pcr/naat if we swab a lesion
(3-4 times more sensitive than a culture)

34
Q

t or f hsv1 and 2 are included in a standard std pannel

A

false it is not included, pt may never get S+S and if the infection is latent we may never know where it is

35
Q

what happens if a pt is on suppressors and gets an ulcer

A

it is likely something else

36
Q

how long is the chickenpox incubation period and can we spread it

A

14 to 15 days, yes can spread in this time

37
Q

how do the chicken pox skin lesions progress

A

macule -> papule -> vesicle -> pustule -> scab

38
Q

when is chickenpox no longer infectious

A

when it is a scab

39
Q

what are complications of varicella

A

-bacterial infection of a skin lesion, cerebral ataxia, encephalites, meningitis, transverse myelitis, reye syndrome (that can have neurological symptoms), pneumonia

40
Q

who is at risk for the herp complications

A

adults, immunocomp, prego, newborn

41
Q

how can we diagnose varicella

A

-hx or physocal exam
-pcr
-culture (less sensitive test)
-serology (more for immunity)

42
Q

t or f a chicken pox spot can also become an abscess or cellulitis

A

true

43
Q

how are we treating chickenpox

A

systomatically with antipyretics, soaks, antipruritics

44
Q

what can we do for adults esp immunocomp w chicken pox

A

AVC, famiciclovir and valacyclovir

45
Q

can immunocomp get the shingles vax

A

yes they can it is no longer a live vax and there is no risk of developing the pox

46
Q

what preceedes the shingles skin lesion by 2-3 days

A

pain

47
Q

if you are over 50 what do u have the risk of in shingles

A

-postherpetic neuralgia which can can happen 25-50% of the time
-life long nerve pain

48
Q

what does the shingles follow

A

the nerve/ dermatone

49
Q

what is diseminated neuralgia

A

shingles on the whole body
-very serious

50
Q

what are the risk factors for postherpetic neuralgia

A

over 50, severe pain before or after onset of rash, extensive rash, tigenimal or othalmic distribution of the rash

51
Q

can shingles affect the vision

A

yes it may never recover

52
Q

neurological complications of shingles

A

-myelitis, encephalitis, ventriculitis, meningoencephalitis, cranial nerve palsies, ischemic stroke syndrome

53
Q

cutaneous dissemination, pneumonia, hepatitis, disseminated intravascular coagulation is?

A

vzv viremia/ disceminated zoster

54
Q

can someone who never got the pox get the shingles

A

yes if they get it from a person with zoster
-lower risk tho
-direct contact with the lesion, MAYBE airbone

55
Q

when is local zoster contageous

A

-when the rash erupts to when the lesion gets crusty

56
Q

how to diagnose zoster

A

-pcr, dfa, culture (not as sensitive), serology (for immunity)

57
Q

how to treat zoster

A

acyclovir and valacyclovir
-IV acyclovir if it is more severe

58
Q

what is the shingles vax

A

shingrix
-recombinant zoster

59
Q

what is the older vax

A

zostavax

60
Q

how is ebv transmitted

A

saliva
-causes mono
-can feel like a cold

61
Q

who is at risk for lymphoroliferative disorder from ebv

A

-immuncomp, aids, transplant

62
Q

why does mono cause hepatosplenomegaly

A

it goes to b cells. lymphocytes

63
Q

clinical manifestation mono

A

fever, malaise, pharyngitis, cervical lymphadenopathy, hepatosplenomegaly, nausea, fever

64
Q

complications of mono

A

laryngeal obstruction, splenic rupture, autoimmune hemolytic anemia, meningocephalitis, guillain barre

65
Q

what is monospot and what is it detecting

A

rapid test for mono that detects antibodies
-but can be caused by other things not ebv

66
Q
A