heritability

Question 1

autism

Answer 1

90%

Question 2

Anorexia Nervosa

Answer 2

55%

Question 3

schizophrenia

Answer 3

70-85%

Question 4

BPAD

Answer 4

60-85%

Question 5

ADHD

Answer 5

60-90%

Question 6

OCD

Answer 6

60-70%

Question 7

Bulimia

Answer 7

60%

Question 8

Alcohol dependence

Answer 8

60%

Question 9

Panic disorder

Answer 9

40-50%

Question 10

MDD

Answer 10

40%

Question 11

Phobia

Answer 11

35%

Question 12

GAD

Answer 12

30%

Question 13

What genetic variant is linked with risk of bipolar disorder

Answer 13

Variant at risk locus ADCY2

Strongest evidence for DAOA and BNDF

Chromosome 11 DiBD1 is disrupted in BPAD1

Question 14

What genetic variant is linked with early onset AD

Answer 14

APOE-e4 variant of Apoe gene

Question 15

What genetic variant is linked with both schizophrenia and bipolar disorder

Answer 15

Variants in DNA methylation

Question 16

Involved genetic variant most likely to result in a good response to SSRI

Answer 16

5HTT gene L genotype

Question 17

Genes in schizophrenia

Answer 17

Dysbidin
Neureglin
22q11 (also implicated in diGeorges)
13q
GAD1 variation
D-Amino oxidase activator on 13q34

Question 18

Gene implicated in depression

Answer 18

5HTT L genotype, implicated in stress reactivity which indirectly leads to depression (short allele of serotonin transporter region)

Question 19

Genes involved in ASD

Answer 19

EN2
Serotonin transporter gene SLC6A4

Question 20

High MAO-A activity protects against this condition development

Answer 20

Antisocial behaviour (MAO A enzyme located on chromosome X)

Question 21

Chromosome 17 linkage associated with…?

Answer 21

FTD

Question 22

Site of COMT gene linked to dopamine in frontal cortex. A CAL polymorphism reduces availability of pre frontal dopamine

Answer 22

22q11