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BPT Oncology > Hereditary Cancer Syndromes > Flashcards

Hereditary Cancer Syndromes Flashcards

1
Q

What is the most common inheritance pattern in hereditary cancer syndromes?

A

autosomal dominant

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2
Q

What is the risk of breast cancer in patients with BRCA mutation?

A

70%

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3
Q

What is the risk of ovarian cancer in patienrs with BRCA1 mutation?

A

44%

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4
Q

What is the risk of ovarian cancer in patients with BRCA2 mutation?

A

17%

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5
Q

What is the risk of prostate cancer in patients with BRCA1 mutation?

A

8.6%

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6
Q

What is the risk of prostate cancer in patients with BRCA2 mutation?

A

15%

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7
Q

What is the risk of pancreatic cancer in patients with BRCA mutation?

A

<5%

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8
Q

What is the risk of colorectal cancer in patients with lynch syndrome?

A

38%

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9
Q

What is the risk of colorectal cancer in patients with FAP?

A

> 95%

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10
Q

What is the risk of ovarian cancer in patients with lynch syndrome?

A

9%

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11
Q

What is the risk of endometrial cancer in patients with lynch syndrome?

A

33%

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12
Q

What is the recommendation for patients with BRCA mutations for cancer screening/protection?

A

breast screening to commence at age 25, bilateral salpingoophorectomy from 40 years (or 5 years younger than earliest person affected)

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13
Q

What is the recommendation for patients with lynch syndrome for cancer screening?

A

colonoscopy from 25 and hysterectomy/oophorectomy at 40 (or 5 years younger than earliest person affected)

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14
Q

What is the recommendation for patients with FAP for cancer screening?

A

colonoscopies from 12 years old

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15
Q

What screening is required for patients with VHL?

A

check BP from 2 years old, annual plasma/urine metanephrines from 2 years old, abdominal US/MRI from 10 years old

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16
Q

What type of breast cancer are you more likely to get with BRCA1 mutation?

A

triple negative

17
Q

What type of ovarian cancer are you more likely to get with BRCA mutation?

A

high grade serous

18
Q

Which patients are offered genetic testing?

A

when the risk of mutation is greater than 10%

BPT Oncology (10 decks)

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