HepB Meds

Question 1

Epivir

Answer 1

Lamivudine

Question 2

Hepsera

Answer 2

Adefovir

Question 3

Viread

Answer 3

Tenofovir

Question 4

Baraclude

Answer 4

Entecavir

Question 5

Tyzeka

Answer 5

Telbivudine

Question 6

First line agents

Answer 6

Tenofovir and Entecavir

Question 7

Nucleoside Reverse Transcriptase Inhibitors Entire Class

Answer 7

Dose reductions for CrCl less than 50

BBW for lactic acidosis and HBV exacerbation upon discontinuation

Question 8

Lamivudine BBW

Answer 8

Additional BBW against use of Epivir HBV for treatment of HIV (contains lower dose of lamivudine)

Question 9

Adefovir BBW

Answer 9

Additional BBW for inducing HIV resistance in undiagnosed HIV patients

Question 10

Special Safety/SE/Monitorin

Answer 10

Adefovir - use caution in patients with renal impairment
tenofovir - falcon syndrome, renal insuff, osteomalacia and decrease bone density
entecavir - take on an empty stomach!!!!
telbivudine - monitor CPK

Question 11

Interferon alfa

Answer 11

Indicated for treatment of HBV AND HCV

Question 12

Interferon alfa Safety SE and Monitorin

Answer 12

BBW - may cause or exacerbate autoimmune disorders, infectious disorders, ischemic and hemorrhagic CVD events. Combo treatment with ribavirin may cause birth defects and hemolytic anemia
SE include flu like sx (can pre treat with APAP and antihistamine) CNS effects (fatigue, anxiety, depression), LFT elevation, myelosuppresion and alopecia