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Micro2 Unit 6 > Hepatitis Viruses > Flashcards

Hepatitis Viruses Flashcards

1
Q

what is the similarity among the hepatitis viruses?

A

they all infect hepatocytes (not related otherwise)

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2
Q

which of the hepatitis viruses can cause acute hepatitis?

A

A-E

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3
Q

which hepatitis viruses cause more severe acute illness?

A

A and E are more severe than B and C

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4
Q

how are the hepatitis viruses transmitted?

A

A and E are fecal/oral route

B, C and D are transmitted via sex, birth and blood

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5
Q

which hepatitis viruses are controlled by vaccination?

A

A, B and hopefully E

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6
Q

where is hepatitis A endemic? hepatitis E?

A

mexico and south America

asia and mexico

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7
Q

which hepatitis virus causes complications of pregnancy?

A

hepatitis E

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8
Q

what is required for hepatitis D infection? what does this mean?

A

hepatitis B coinfection

the HepB vaccination is also protective against hep D

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9
Q

what is the implication of coinfection of Hep B and D?

A

high risk of bad outcomes

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10
Q

what do serology results for HepA mean?

A

IgM- acute

IgG- recovered/vaccinated

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11
Q

what do the different serology results for HepB mean?

A

viral surface antigen- acute

IgG against surface antigen- recovered/vaccinated

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12
Q

what are the possible serology results for HepC?

A

EIA- real or false positive

RIBI- confirmation of positive

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13
Q

what serology results indicate hep D?

A

delta antigen

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14
Q

which hepatitis viruses can cause chronic disease? what sequelae may result?

A

hep B and C

cirrhosis and or cancer

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15
Q

what is the result of interferon treatment for chronic hepatitis?

A

many side effects with limited efficacy

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16
Q

what can IFN be combined with to improve cure of HepC?

A

second generation protease inhibitors

third generation inhibitors of protease polymerase and NS5A (newer)

17
Q

what immune decoys are produced by HepB? what might they cause?

A

surface antigen alone

immune complexes may cause disease

18
Q

what difficulty is faced in treating HepC?

A

when established, forms a large number of mutant viruses that make immunity and treatment difficult to target

19
Q

what may be the result of liver transplant for chronic Hep B or C?

A

reinfection from secondary sites

20
Q

what context makes chronic hepatitis B and C difficult to treat?

A

HIV

Micro2 Unit 6 (6 decks)

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