Hemophilus and Bordetella Flashcards
how are haemophilus and bordetella cultured?
fastidious- require factors X and V in vitro
how are haemophilus and bordetella transferred? what illnesses do they usually cause?
respiratory droplets
pediatric respiratory infection
how are haemophilus and bordetella treated?
vaccine is available
treat with antibiotics and supportive care
describe the morphology of haemophilus.
gram negative, pleomorphic organisms
they can be cocci and rods with or without a capsule
what causes H flu to be more pathogenic? what prevention does this allow?
capsule
capsulated are covered by vaccine (unencapsulated are not)
what follows URI with encapsulated H flu?
bacteremia and invasive disease
what invasive diseases are caused by encapsulated H flu?
meningitis, cellultis, epiglottiis and septic arthritis
where does nonencapsulated H flu reside? what virulence factors does it posess?
normal flora
IgA protease, pili and adhesins
what illnesses are caused by unencapsulated h flu?
neonatal and postpartum sepsis, CF pneumonia and systemic complications
when is complicated infection with H flu more likely?
with respiratory or immune predisposition leading to defective defense mechanisms
what is the morphology of B pertussis? why is incidence increasing?
short gram negative rod
inadequate vaccine coverage
describe the vaccines for B pertussis used in the US and abroad
the acellular vaccine in the US has shorter lived protection than the killed cell vaccine used abroad
how does pertussis attach to ciliated cells? how does it cause damage?
filamentous hemaggltinin pilus attaches the bacteria and exotoxin causes cilliary stasis
describe the contagiousness and prognosis of B pertussis
very contagious and spread by coughing
prognosis is good without bacteremia
what disease does B pertussis caused? what is the clinical course?
whooping cough
prolonged cough paroxysms for about three months, even with treatment
