Hepatitis B Flashcards
1
Q
What cell types does it target?
A
Hepatocytes (liver cells)
2
Q
What receptor is targeted?
A
NTCP
3
Q
How does the virus enter the cell?
A
RM endocytosis
4
Q
How does HBV present?
A
Jaundice, liver problems
5
Q
How is the genome structured?
A
In relaxed circular DNA form (ie there is a nick in one strand)
6
Q
What type of genome is HBV?
A
ds DNA
7
Q
What occurs in the nucleus?
A
RC DNA converted to cccDNA (covalently closed circular DNA) and binds histones to create a stable plasmid type structure.
8
Q
Where does budding occur?
A
Endoplasmic Reticulum
9
Q
Does HBV contain reverse transcriptase?
A
Yes! It is carried inside the NC
10
Q
What family is HBV in?
A
Hepadnaviridae
11
Q
What TLRs would detect this virus?
A
TLR9 (for dsDNA genomes)
