Hepatitis B Flashcards
1
Q
Hepatitis B definition
A
- liver infection caused by Hep B virus
- HBV is a dsDNA virus transmitted by blood, sexual activity or vertically
2
Q
Hepatitis B risk factors
A
- perinatal exposure
- high risk sexual behaviour
- IV drug use
- birth in endemic region
- family history
- history of incarceration
3
Q
Hepatitis B pathophysiology
A
liver damage secondary to host immune response to viral antigens
4
Q
Hepatitis B signs and symptoms
A
- incubation for 6-20 weeks
- may be asymptomatic
- acute - fever, jaundice, LFTs
- long-term - HCC, chronic hepatitis, fulminant liver failure, glomerulonephritis, polyarteritis nodosa, cryoglobulinaemia
5
Q
Hepatitis B investigations
A
- FBC, U&Es, LFTs, coagulation, HBV bloods
- consider ultrasound, CT, biopsy
- ground-glass hepatocytes on histology
6
Q
Hepatitis B management
A
- pegylated interferon-alpha
- antivirals
- liver transplant
- immunisation!
7
Q
HBsAg
A
acute infection + infectious
8
Q
HBsAb/anti-HBS
A
- immunised or previous infection
- only HBaAb positive - immunised
9
Q
HBcAb
A
previous or current infection
10
Q
IgM anti-HBc
A
acute infection
11
Q
IgG anti-HBc
A
previous infection
