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IS - FINALS - MTAP1.3 > Hepatitis B > Flashcards

Hepatitis B Flashcards

1
Q

other name for Hepatitis B

A

Dane Particle

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2
Q

acute -> chronic; more fatal and severe than Hepatitis A

A

Viral Infection

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3
Q

Hepa B Virology

A

Hepadnaviridae
Double-stranded DNA

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4
Q

Incubation Period

A

45-160 days

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5
Q

Average

A

120 days

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6
Q

Hepa B MOT

A

Parenteral
Sexual
Perinatal

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7
Q

Best indicator of early and acute infection

A

HBsAg

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8
Q

Presence indicates active infection (acute or chronic
stage)

A

HBsAg

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8
Q

HBsAg previously known as the ______

A

Australian Antigen

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9
Q

Found within the core of intact virus/viral agent

A

HBcAg

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10
Q

HBcAg specimen

A

found in the hepatocytes
liver biopsy

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11
Q

Indicates chronic hepatitis

A

HBeAg

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12
Q

HBeAg is a reliable marker for the presence of

A

↑ level of viral load = ↑ degree of infectivity

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13
Q

First antibody to appear
asymptomatic carrier
window period of infection

A

anti-HBc

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14
Q

convalescence phase or
recovery period

A

anti-HBe

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15
Q

anti-HBe may also indicate

A

decrease level of viral load = level of infectivity

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16
Q

Bestows long term immunity to HBV infection

A

Anti-HBs

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17
Q

made by recombinant strain of the yeast

A

HBV Vaccine (1982)

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18
Q

common bakers’ yeast

A

Saccharomyces cerevisiae

19
Q

Ouchterclony

A

1st generation

20
Q

Ouchterclony
Principle:

A

Precipitation Reaction Double Diffusion or Dimension

21
Q

CIE
Rheophoresis
Complement Fixation

A

2nd generation

22
Q

Counter
Immunoelectrophoresis (CIE) Principle

A

Precipitation Reaction with
Current

23
Q

Rheophoresis Principle

A

Precipitation Reaction by
Evaporation

24
Q

Reverse Passive Latex Agglutination
Reverse Passive Hemagglutination
ELISA
RIA

A

3rd generation

25
Q

Commonly used to confirm Hepatitis B infection

A

ELISA

26
Q

Hepatitis B antigen

A

Direct ELISA

27
Q

Hepatitis B antibody

A

Indirect ELISA

28
Q

Reverse Passive Latex Agglutination
- Antibodies are artificially coated with ____ particle

A

latex

29
Q

Reverse Passive Hemagglutination
- Antibodies are artificially coated with _____

A

red blood cells

30
Q

severe, sudden onset

A

Fulminant Hepatitis

31
Q

asymptomatic carrier
chronic persistent hepatitis
chronic active hepatitis

A

Chronic Hepatitis

32
Q

Hepatitis D requires the
surface antigen of Hepatitis B to replicate

A

Co-infection with Hepatitis Delta Virus (HDV)

33
Q

If Hepatitis B is not managed it can progress to ________

A

Primary Hepatocellular
Carcinoma (Liver Cancer) aka hepatoma

34
Q

Examples of Infectious Cancer:
- Hepatitis B Virus
- Human Papilloma Virus
- Epstein-Barr Virus

A

Hepatoma
Cervical Cancer
Nasopharyngeal Cancer

35
Q

 Active disease
 chronic/acute in nature

A

HBsAg

36
Q

 No active disease
 Long term immunization
 Patient is already cured

A

anti-HBsAg

37
Q

IgM Anti-HBcAg

A

New infection

38
Q

IgG Anti-HBcAg

A

Old infection

39
Q

BOTH PRESENT
(IgM + IgG Anti-HBcAg)

A

mid-infection

40
Q

↑ viral load = ↑ level of infectivity

A

HBeAg

41
Q

decrease viral load
decrease level of infectivity

A

Anti-HbeAg

42
Q

Serologic test on donor blood

A

HBsAg screening
SGPT/ALT

43
Q

for treatment of chronic or persistent HBV infection

A

Anti-viral agents

44
Q

Anti-HBV drug

A

Lamivudine

45
Q

Treatment with interferon ____

A

alpha

IS - FINALS - MTAP1.3 (6 decks)

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