Hepatitis B

Question 1

other name for Hepatitis B

Answer 1

Dane Particle

Question 2

acute -> chronic; more fatal and severe than Hepatitis A

Answer 2

Viral Infection

Question 3

Hepa B Virology

Answer 3

Hepadnaviridae
Double-stranded DNA

Question 4

Incubation Period

Answer 4

45-160 days

Question 5

Average

Answer 5

120 days

Question 6

Hepa B MOT

Answer 6

Parenteral
Sexual
Perinatal

Question 7

Best indicator of early and acute infection

Answer 7

HBsAg

Question 8

Presence indicates active infection (acute or chronic
stage)

Answer 8

HBsAg

Question 8

HBsAg previously known as the ______

Answer 8

Australian Antigen

Question 9

Found within the core of intact virus/viral agent

Answer 9

HBcAg

Question 10

HBcAg specimen

Answer 10

found in the hepatocytes
liver biopsy

Question 11

Indicates chronic hepatitis

Answer 11

HBeAg

Question 12

HBeAg is a reliable marker for the presence of

Answer 12

↑ level of viral load = ↑ degree of infectivity

Question 13

First antibody to appear
asymptomatic carrier
window period of infection

Answer 13

anti-HBc

Question 14

convalescence phase or
recovery period

Answer 14

anti-HBe

Question 15

anti-HBe may also indicate

Answer 15

decrease level of viral load = level of infectivity

Question 16

Bestows long term immunity to HBV infection

Answer 16

Anti-HBs

Question 17

made by recombinant strain of the yeast

Answer 17

HBV Vaccine (1982)

Question 18

common bakers’ yeast

Answer 18

Saccharomyces cerevisiae

Question 19

Ouchterclony

Answer 19

1st generation

Question 20

Ouchterclony
Principle:

Answer 20

Precipitation Reaction Double Diffusion or Dimension

Question 21

CIE
Rheophoresis
Complement Fixation

Answer 21

2nd generation

Question 22

Counter
Immunoelectrophoresis (CIE) Principle

Answer 22

Precipitation Reaction with
Current

Question 23

Rheophoresis Principle

Answer 23

Precipitation Reaction by
Evaporation

Question 24

Reverse Passive Latex Agglutination Reverse Passive Hemagglutination ELISA RIA

Answer 24

3rd generation

Question 25

Commonly used to confirm Hepatitis B infection

Answer 25

ELISA

Question 26

Hepatitis B antigen

Answer 26

Direct ELISA

Question 27

Hepatitis B antibody

Answer 27

Indirect ELISA

Question 28

Reverse Passive Latex Agglutination - Antibodies are artificially coated with ____ particle

Answer 28

latex

Question 29

Reverse Passive Hemagglutination - Antibodies are artificially coated with _____

Answer 29

red blood cells

Question 30

severe, sudden onset

Answer 30

Fulminant Hepatitis

Question 31

asymptomatic carrier chronic persistent hepatitis chronic active hepatitis

Answer 31

Chronic Hepatitis

Question 32

Hepatitis D requires the surface antigen of Hepatitis B to replicate

Answer 32

Co-infection with Hepatitis Delta Virus (HDV)

Question 33

If Hepatitis B is not managed it can progress to ________

Answer 33

Primary Hepatocellular Carcinoma (Liver Cancer) aka hepatoma

Question 34

Examples of Infectious Cancer: - Hepatitis B Virus - Human Papilloma Virus - Epstein-Barr Virus

Answer 34

Hepatoma Cervical Cancer Nasopharyngeal Cancer

Question 35

 Active disease  chronic/acute in nature

Answer 35

HBsAg

Question 36

 No active disease  Long term immunization  Patient is already cured

Answer 36

anti-HBsAg

Question 37

IgM Anti-HBcAg

Answer 37

New infection

Question 38

IgG Anti-HBcAg

Answer 38

Old infection

Question 39

BOTH PRESENT (IgM + IgG Anti-HBcAg)

Answer 39

mid-infection

Question 40

↑ viral load = ↑ level of infectivity

Answer 40

HBeAg

Question 41

decrease viral load decrease level of infectivity

Answer 41

Anti-HbeAg

Question 42

Serologic test on donor blood

Answer 42

HBsAg screening SGPT/ALT

Question 43

for treatment of chronic or persistent HBV infection

Answer 43

Anti-viral agents

Question 44

Anti-HBV drug

Answer 44

Lamivudine

Question 45

Treatment with interferon ____

Answer 45

alpha