Hepatitis Flashcards
1
Q
Lab diagnosis of Hep A
A
Acute infection: HAV-IgM
Chronic infection: HAV-IgG
2
Q
3 Ag and Ab systems of Hep B
A
HBsAg — anti-HBs
HBcAg — anti-HBc
HBeAg — anti-HBe
3
Q
HBsAg
A
- persist for many years in chronic patients or carriers
- marker of infectivity
- found in humours and secretions
4
Q
anti-HBs
A
- appear after HBsAg disappear for several weeks
* protective antibody, can persist for many years
5
Q
HBcAg
A
- found in nuclei
* marker of replication of HBV
6
Q
Anti-HBc IgM
A
• Marker of acute infection & acute attack of chronic infection of HBV
7
Q
Anti-HBc IgG
A
- marker of past infection
* low level replication of HBV
8
Q
HBeAg
A
Indicator of active replication of HBV
9
Q
Anti-HBe
A
- Marker of reduced infectivity
* if exists for a long time, marker of integration of HBV into liver cell
10
Q
Lab diagnosis of Hep C
A
- HCV antibody
- HCV-RNA
- HCV-antigen
11
Q
HCV antibody
A
• used for diagnosis of Hep C infection (but not useful in acute phase)
12
Q
HCV-RNA
A
- monitoring response to antiviral therapy
* diagnose HCV infection in acute phase
