Hepatitis Flashcards
Peak titers of ______ occur during the first week of clinical disease and disappear within 3-6 months
IgM
Titers of ______ rise after one month of the disease an may persist for years
IgG
_____ in the absence of ____ indicates previous exposure to hep A virus, non infectivity an immunity
IgG without IgM
Hep A has an incubation time of __________
4 weeks
Detect _______ during acute illness when serum aminotransferase is high and fecal shedding is still occuring
anti-HAV
Early antibody response is _____ - for 3 months
IgM
During recovery _______ becomes dominant
anti-HAV IgG
To make an early diagnosis use early __________
IgM anti-HAV
After illness, __________ remains detectable indefinitely, pts that establish this are immune to reinfection
anti-HAV IgG
First virologic marker of Hep B
HBsAg
_________remains elevated during the entire time of acute hep B and beyond
HBsAg
Earliest marker of Hep B
HBsAg
_________is a core antibody- reflects infection in the past but is not useful by itself
Anti-HBc
_________ appears during incubation period, shortly after the detection of HBsAg
HBeAg
_________ indicates viral infectivity
HBeAg
Persistence of _________beyond 3 months indicates and increased likelihood of chronic hep B
HBeAg
__________signifys diminished viral replication and decreased infectivity
anti-HBe
The presence of ________ is the most specific and sensitive to early detection of hep B
HBV-DNA
Serum aminotransferase are ______in hep B
higher
___________positive mothers may transmit HBV at delivery
HBsAg
When to admit with Hep B
encephalopathy
liver failure
unable to maintain hydration
______________ indicates that you either have hep C now or you have had it at some point
Anti-HCV
Treatment with ____________ for 6-24 decreases the risk of chronic hep C
peginterferon
_____________ may be added if HCV RNA is not cleared after 3 months of peginterferon
ribaviran
