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GI > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

Hbsag becomes undetectable _____ after onset of jaundice

A

after 1-2 mos

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2
Q

When does antiHBc appear in the serum

A

Within the first 1-2 weeks after appearance of HBsAg

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3
Q

HbsAg levels detectable when

A

Within 1-12 weeks

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4
Q

HCV gains entry into the hepatocytes through this receptor

A

CD81 receptors

claudin-1

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5
Q

Most sensitive HCV infection

A

HCV RNA

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6
Q

Entirely transmitted NonA NonB hepatitis

A

Hep E

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7
Q

extrahepatic manifestations of Hep

A

serum-sickness like syndrome
GN
generalized vasculitis
essential mixed cryoglobulinemia

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8
Q

Hep B; arthritis, cutaneous vasculitis (palpable purpura) +/- GN with circulating cryoprecipitable immune complexes of more than one immunoglobulin class

A

essential mixed cryoglobulinemia

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9
Q

acidophilic degeneration of hepatocytes

A

councilman/apoptptic bodies

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10
Q

Liver damage in hepatitis

A
  • hepatitis cell degeneration and necrosis
  • cell dropout
  • ballooning of cells
  • acidophilic degeneration of hepatocytes
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11
Q

Large hepatocytes with ground glass appearance

A

chronic hepatitis

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12
Q

paucity of inflammation
increase in activation of sinusoidal lining cells
lymphoid aggregate

A

Hepa C

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13
Q

Hepatitis

microvesicular steatosis

A

Hepa D

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14
Q

common histologic feature is marked cholestasis

A

Hep E

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15
Q

Component of the “bridge”

A
  1. condensed reticulum
  2. inflammatory debris
  3. degenerating liver cells that span adjacent portal areas
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16
Q

fulminant hepatitis

“acute yellow atrophy”

A

massive hepatic necrosis

17
Q

subacute or confluent necrosis

interface hepatitis

A

bridging hepatic necrosis

18
Q

AE of interferon therapy for Hepa B that is not reversible upon dose lowering

A

Autoimmune hepatitis

19
Q

High risk individuals that should receive screening for hep B

A

CHIMPA h-3 i-3 m-2

Countries endemic
Household contacts
HCV/HIV patients
HD patients
Inmates
Injection drugs
Immunosuppressed
MSM
Multiple sex contacts
Pregnant
ALT or AsT elevated
20
Q

Jaundice in sclera

A

> 43 umol or 2.5 mg/dl

21
Q

First approved therapy for hepa B

A

Interferon

22
Q

MOA lamivudine

A

Inhibits reverse transcriptase activity of HIV and HBV

23
Q

Monotherapy of ____ can induce YMDD variants in patients with HIV infection

A

Lamivudine

24
Q

First line therapy of choice in HBeAg reactive chronic hepatitis B

A

PEG IFN monotheraoy

25
Q

antiviral therapy is recommended hepatitis

A

HBeAg-negative chronic hepatitis B
ALT >2 x the upper limit of normal
HBV DNA >2 x 103 IU/ml

GI (9 decks)

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