Hepatitis

Question 1

HAV and HEV Transmission (general and specific)

Answer 1

FO
HAV by Travelers
HEV with contaminated water/shellfish

Question 2

HAV and HEV Chronicity and Serology

Answer 2

Only acute, no chronic

IgM marks active infection, IgG indicates previous infection or immunization (only HAV)

Question 3

HEV Complication

Answer 3

Fulminant hepatitis in pregnant women

Question 4

HBV Transmission and Chronicity

Answer 4

Parenteral (childbirth, unprotected sex, IVDA). Generally only acute, chronicity in 20%

Question 5

HCV Transmission, Chronicity, and Serology

Answer 5

Parenteral (almost never transfusion)
Chronic in most cases
HCV-RNA confirms infection, decreased indicates recovery, persistence indicates chronic

Question 6

HDV Coinfection vs. Superinfection

Answer 6

Co: HDV and HBV at the same time
Super: HDV onto existing HBV. More severe

Question 7

HBV Serology (4)

Answer 7

HBsAg is first to rise, can disappear in window, but presence after 6 months indicates chronic
HBeAg and HBV-DNA indicate person still infectious (either acute or chronic. Lack of in chronic means noninfectious carrier)
HBcAb is IgM first, only thing you can see in window period. Will go to IgG in resolved/chronic
HBsAb IgG means victory/protection and infection resolved or immunized