Hepatic Phys And Anesthesia Flashcards

1
Q

What is not a apart of MELD score?

A

Serum albumin

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2
Q

Which is a more objective score Child-Pugh ?

A

Meld because it does not look at things that are subjective such as encephalopathy or as cities

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3
Q

What are the components of the MELD score?

A

Serum creatinine
Bilirubin
INR

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4
Q

What enzyme is messed up in Gilbert syndrome?

A

Bilirubin glucoronyltransferase

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5
Q

What happens in Gilbert with massive blood transfusion

A

Postoperative jaundice due to overwhelming of the enzyme

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6
Q

What does glucagon do to hepatic blood flow?

A

Increases it along with D1 and Beta 2 receptors in the hepatic artery

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7
Q

How much cardiac output does the liver receive.

A

25%

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8
Q

Which vessel to the liver exhibits autoregulation?

A

Hepatic artery

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9
Q

What happens to the hepatic arterial flow when portal vein decreases?

A

It will increase due to accumulation of adenosine which causes vasodilation via the A2 receptors

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10
Q

What agents decrease hepatic blood flow?

A

Beta blockers due to the beta 2 in the hepatic artery

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11
Q

What do alpha receptors do to hepatic blood flow?

A

Decrease it

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12
Q

What does vasopressin do to hepatic blood flow?

A

Decreases it

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13
Q

What do D1 receptors do to hepatic blood flow?

A

Decrease it

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14
Q

What happens to hepatic blood flow in general anesthesia?

A

It decreases due to decreased cardiac output

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15
Q

Where is citrate metabolized?

A

The liver

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16
Q

What is citrate metabolized to?

A

Bicarbonate

17
Q

What does glucagon do to hepatic blood flow?

A

Increases it along with D1 and Beta 2 receptors in the hepatic artery

18
Q

How much cardiac output does the liver receive.

A

25%

19
Q

Which vessel to the liver exhibits autoregulation?

A

Hepatic artery

20
Q

What happens to the hepatic arterial flow when portal vein decreases?

A

It will increase due to accumulation of adenosine which causes vasodilation via the A2 receptors

21
Q

What agents decrease hepatic blood flow?

A

Beta blockers due to the beta 2 in the hepatic artery

22
Q

What do alpha receptors do to hepatic blood flow?

A

Decrease it

23
Q

What does vasopressin do to hepatic blood flow?

A

Decreases it

24
Q

What do D1 receptors do to hepatic blood flow?

A

Decrease it

25
Q

What happens to hepatic blood flow in general anesthesia?

A

It decreases due to decreased cardiac output

26
Q

Where is citrate metabolized?

A

The liver

27
Q

What is citrate metabolized to?

A

Bicarbonate

28
Q

What does cytochrome P450 do?

A

Oxidizes organic compounds

29
Q

Where is cytochrome p450?

A

Endoplasmic reticulum

30
Q

What mineral is associated with cytochrome p450?

A

Iron

31
Q

What is metabolized by the 2C19 system?

A

Plavix

32
Q

What is metabolized by 2D6?

A

Codeine to morphine

33
Q

What is metabolized by 3A4?

A

Midazolam
Lidocaine
Oral contraceptives
Alfentanil

34
Q

What is metabolized by the 2C19 system?

A

Plavix

35
Q

What is metabolized by 2D6?

A

Codeine to morphine

36
Q

What is metabolized by 3A4?

A

Midazolam
Lidocaine
Oral contraceptives
Alfentanil