Hepatic Impairment Flashcards
1
Q
Questions to ask in hepatic impairment?
A
- What is the type of liver disease and cause?
- What are the results of immunological/ virological screens and other diagnostic tests (biopsies)
- Symptoms, extent and severity?
- Liver function tests
- How is patient’s renal function?
2
Q
Liver function tests
A
bilirubin, alkaline phosphatase, ALT, AST, GGT
and
albumin, INR
- Are they stable or changing?
3
Q
If requesting advice on dosage or suitability of a drug in hepatic dysfunction
A
- What agent would normally be used if the patient did not have liver dysfunction?
- Have alternatives been considered?
4
Q
If suspected that hepatic impairment is drug-induced
A
- Is the patient still taking the drug?
- Dose, frequency and duration of treatment of the suspected drug
- Type of liver injury
- How patient has been managed
- Which other drugs are being taken or were taken recently?
- Could there be another cause?