Hepatic Impairment Flashcards

1
Q

Questions to ask in hepatic impairment?

A
  1. What is the type of liver disease and cause?
  2. What are the results of immunological/ virological screens and other diagnostic tests (biopsies)
  3. Symptoms, extent and severity?
  4. Liver function tests
  5. How is renal function?
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2
Q

Liver function tests

A

bilirubin, alkaline phosphatase, ALT, AST, GGT
and
albumin, INR
- Are they stable or changing?

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3
Q

If requesting advice on dosage or suitability of a drug in hepatic dysfunction

A
  • What agent would normally be used if the patient did not have liver dysfunction?
  • Have alternatives been considered?
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4
Q

If suspected that hepatic impairment is drug-induced

A
  • Is the patient still taking the drug?
  • Dose, frequency and duration of treatment of the suspected drug
  • Type of liver injury
  • How patient has been managed
  • Which other drugs are being taken or were taken recently?
  • Could there be another cause?
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