Hepatic and Biliary Flashcards

1
Q
A
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2
Q

Where does the liver refer to?

A
  • Thoracic spine (7-10) midline - to the right
  • Right upper trap and shoulder
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3
Q

Where does the gallbladder refer to?

A
  • Right upper trap and shoulder
  • Right interscapular area (T4-8)
  • Right subscapular area
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4
Q

When working with patients with liver disease, what is an important consideration to keep in mind regaurding their bones?

A

Increased risk for hepatic osteodystrophy and osteoporosis

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5
Q

Hepatic osteodystrophy

A

abnormal development of bone

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6
Q

Neurological symptoms associated with liver disease

A
  • Confusion
  • Sleep disturbances
  • Muscle tremors
  • Hyperreactive tremors
  • Asterixis
  • Peripheral n. dysfunction (bilateral carpal tunnel or tarsal tunnel syndrome)
  • Poor concentration
  • Fatigue
  • S&S of encephalopathy
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7
Q

Route of transmission for Hep A, B, and C

A

Hep A: fecal-oral
Hep B + C: percutaneous w/bodily fluid + mucosal

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8
Q

Which acute hepatitis presents with diarrhea?

A

Hep A

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9
Q

What is the potential for chronic infection of Hep A?

A

NONE

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10
Q

What is the potential for chronic infection of Hep B?

A

Infants: 90% after acute infection at birth
Children: 25-50% newly infected at 1-5Y
Adults: 5%

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11
Q

What is the potential for chronic infection of Hep C?

A

> 50% of newly infected people

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12
Q

Long-term Effects of Hep A

A

Most people recover with no lasting liver damage.

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13
Q

Long-term Effect of Hep B

A
  • Most recover with no lasting liver damage.
  • 15-25% will develop chronic liver infection
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14
Q

Long Term Effects of Hep C

A

5-25% of people develop cirrhosis/10-20Y
Hep C + cirrhosis = 1-4% annual risk for hepatocellular carcinoma

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15
Q

Treatment for Hep A

A

Supportive treatment only

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16
Q

Treatment for Hep B

A

Acute: supportive treatment
Chronic: regular monitoring for signs of liver disease progression; antiviral drugs available

17
Q

Treatment for Hep C

A

Acute: immediate treatment
Chronic: Over 90% of people can be cured w/8-12 weeks of oral therapy

18
Q

Vaccination Hep A

A
  • Single antigen hepatitis vaccine: 2 doses, 6-18M apart
  • Combo HepA/B vaccine: 3 doses/6M
19
Q

Vaccination Hep B

A

Infant and children: 3-4 doses over 6-18M
Adult: 2 does 1M apart or 3 doses over 6M
Combo HepA/B vaccine: 3 doses/6M

20
Q

Vaccination Hep C

A

No vaccine available

21
Q

Hep A Risk Factors

A
  • Household/sexual contact
  • Homosexual Men
  • Drug users
  • Environmental
  • Blood clotting factor recevied pre-1987
22
Q

Hep B Risk Factors

A
  • Drug user
  • Sexual contact
  • Jail
  • Environmental
  • Occupaitonal
  • Infants born to HBV mom
  • Liver transplant recipient, blood products pre 7/1992
  • Sharing items
23
Q

Risk Factor Hep C

A
  • Sharing drug equipment
  • Blood transfusion/organ transplant or blood clotting products pre-1987
  • HIV
  • Occupational (Dialysis pt and staff)
  • ## Infants born to HCV mom
24
Q

General Hepatitis Risk Factors

A
  • Injection drug user
  • Acupunture
  • Tattoo removal or inscription
  • Ear or body piercing
  • Recent operation
  • Liver transplant recipient
  • Blood or plasma transfusion pre-1992
  • Hemodialysis
  • Healthcare worker exposed to blood products or bodily fluids
  • Exposure to certain chemicals or meds
  • Unprotected sex
  • Travel to high-risk areas
  • Consumption of raw shellfish
25
# I present with... - Extreme fatigue - Anorexia - Fever - Arthralgia/myalgia - RUQ abdominal pain - Clay-colored stools - Dark urine - Jaudince - Headache - Pharyngitis - Alteration in sense of taste/smell - Loss of desire to smoke cigarettes or drink EtOH - Low-grade fever - Indigestion
Hepatitis A
26
Why is a mild Hepatitis A infection commonly mis-diagnosed in childhood?
It presents with flu-like symptoms
27
# I present with... - Jaundice - Arthralgia - Rash (entire body) - Dark Urine - Anorexia - Nausea - Painful abdominal bloating - Fever | who am I?
Hep B
28
Which type of Hepatitis can progress to cirrhosis? a. none b. chronic active hepatitis c. chronic persistent hepatitis d. chronic dormant hepatitis
chronic active hepatitis
29
# I present with... - Fatigue - Jaundice - Abdominal pain - Anorexia - Arthralgia - Fever - Splenomegaly + hepatomegaly - Weakness - Ascites - Hepatic encephalopathy | who am I?
Chronic Active Hepatitis
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# I present with... - RUQ Pain - Anorexia - Mild fatigue - Malaise | who am I?
Chronic Persistent Hepatitis
31
What are two metabolic diseases that cause chronic hepatisis?
Wilson's disease and hemochromatosis
32
Wilson's Disease
Impaired biliary excretion of copper = mild to severe neurological involvement
33
Hemachromatosis
Fibrosis of parenchymal organs due to impaired iron storage = arthralgia and arthropathy (commonly 2nd and 3rd MCP joints, first knees/hips/shoulder/LB)
34
# I present with... - Anorexia, N/V - Fatigue/malaise - Dark urine - Clay-colored stools - Headache, dizziness, drowsiness - Fever, rash, arthralgias, epigastric or RUQ pain | who am I?
Toxic/Drug induced hepatitis
35
What is a common hepatotoxic agent?
Acetaminophen
36