Hepatic Anatomy Flashcards
Path of Bile ducts:
Right + Left Hepatic ducts–> Common Hepatic duct
+cyctic Duct = Common Bile duct
Joined by main pancreatic duct–>
through SOD and ampula to dudoenum
Right lobe =
Left lobe=
What two structures keep teh liver from floating freely in abdomen?
What divides L and Right liver?
Coronary ligament on the right lobe + left triangular lobe
the Falciform ligaments divides
Obliterated umbilical vein =
Round ligament of liver
What does the only bare area on teh liver come into contact with?
adheres to diaphragm
What sections of the liver does the Left hepatic vein feed?
Right hepatic vein?
Left: II, III, IV
Right: V, VI, VII, VIII
*parent–> child just section 2 or 3
adult–> adult: 5-8
Why is it hard to damage the pancrease?
located retroperitoneal
Where does liver get its blood supply?
Hepatic artery (comes off abdominal arota) + portal vein
**hard for liver to be ischemic bc of dual blood supply and 70% comes from hepatic artery
What is the role of the sinusoids in liver?
Where does the liver drain into?
This is when blood enters liver and is filtered here.
Will go to Hepatic vein–> Vena Cava
Where are Kupfner cells and what do they do?
located in sinusoids; macrophage cells
fenestrated area, blood can exit out of this to enter hepatocytes
sinusoids
what kind of organ is the liver?
endocrine
What is the funciton of hepatocytes?
make lots of shit adn release to space of disse– to sinudoid–> gets distributed
Describe Space of Disse
located btwn fenestreations adn hepatocytes
some stuf will get stuck in space of Disse and needs to get drained to lymph nodes
Contains stellate cells
What are stellate cells adn where are they located?
Responsible for collagen depostion–> fibrosis–> cirrhosis
In space of Disse
What is a hepactic acinus?
Has Zone 1: more virus and shit
zone 3: ischemic area
• Mechanism for concentration:
absorption of____, ______ and _______,
leads to concentration of bile salts, cholesterol, lecithin and bilirubin
water, sodium and chloride
• Cholesterol and
lecithin are solubilized by
• Volume goes from 500 ml to 50 ml
bile salts
Funciton of Bile Salts:
how does it decrease surface tension?
how does it aid in digetsion of fats?
Emulsification
Forming micells
Micells are made of
Fatty acids, monoglycerides, cholesterol
Fatty foods in duodenum results in release of________
That causes gallbladder contraction and emptying in under 1 hour
CCK
Two functions of CCK
gallbladder contraction and emptying in under 1 hour
o CCK also causes relaxation of the Sphincter of Oddi
What is the role of secretin?
Increases HCO3- release from pancrease (decrease pH)
decrease gastric acid secreation
Increases bile secreation specifically at bile duct of HCO3-, Na+, H2O
Increases pancreatic secreation, increases GB contraction, Incresas SOD relaxation, decreases gatsric emptying
CCK (regulated by FA in teh duodenum)
Acts on biliary epithelium to produce a solution rich in
sodium bicarbonate
o Helps neutralize acids
o Optimizes pancreatic function
secretin
Pancreatic secretions in
response to chyme in upper small intestine with juice
characteristics dependent on :
type of food
General anatomy of pancreas
appreciate it
What does the pancreatic acinus secreate?
What about the pancreatic duct?
Acinus secreates digestive enzymes
Duct secreates bicarb
What form is trypin secreated in?
What enZ actviate trypsin?
Secreted in inactive form: chymotrypsin,
chymotrypsinogen and procarboxypolypeptidase
Proteins —-> proteoses, peptone/polyepetides via what enZ?
Pepsin
Protesose, Peptonse, Polypepetides–> Polypeptides +AA via What enZ?
trypsin, chymotrpysin, carbosypolpeptidase, protealse
• Majority of dietary fats are _______= Glycerol nucleus + 3 fatty acid side chains
• Pancreatic lipase digests them w/in 1 min
Free fatty acids and 2-monoglycerid
triglycerides (TG)
Role of bile salts in fat digestion
Fat acted on by bile –> emulsified fat
emulsifed fat–> pancreatic lipase–> FA + 2 monoglycerides
bile salts form micelles and remove monoglycerides and fatty acids
and transport them to brush border for absorption
Key components of bicarb secreation
have Na adn HCO3- released into the lumen
need to have carbonic anyhdrase helping out with resorbed CO2 and H2O
This shit will neutralize acids so pancreatic enZ can work
•_______- acts on acini to produce
digestive enzymes
•_______- acts on pancreatic duct epithelium
to produce bicarbonate-rich solution
Cholecystokinin
Secretin
