Hepatic Anatomy Flashcards

1
Q

Path of Bile ducts:

A

Right + Left Hepatic ducts–> Common Hepatic duct

+cyctic Duct = Common Bile duct

Joined by main pancreatic duct–>

through SOD and ampula to dudoenum

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2
Q

Right lobe =

Left lobe=

A
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3
Q

What two structures keep teh liver from floating freely in abdomen?

What divides L and Right liver?

A

Coronary ligament on the right lobe + left triangular lobe

the Falciform ligaments divides

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4
Q

Obliterated umbilical vein =

A

Round ligament of liver

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5
Q

What does the only bare area on teh liver come into contact with?

A

adheres to diaphragm

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6
Q

What sections of the liver does the Left hepatic vein feed?

Right hepatic vein?

A

Left: II, III, IV

Right: V, VI, VII, VIII

*parent–> child just section 2 or 3

adult–> adult: 5-8

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7
Q

Why is it hard to damage the pancrease?

A

located retroperitoneal

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8
Q

Where does liver get its blood supply?

A

Hepatic artery (comes off abdominal arota) + portal vein

**hard for liver to be ischemic bc of dual blood supply and 70% comes from hepatic artery

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9
Q

What is the role of the sinusoids in liver?

Where does the liver drain into?

A

This is when blood enters liver and is filtered here.

Will go to Hepatic vein–> Vena Cava

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10
Q

Where are Kupfner cells and what do they do?

A

located in sinusoids; macrophage cells

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11
Q

fenestrated area, blood can exit out of this to enter hepatocytes

A

sinusoids

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12
Q

what kind of organ is the liver?

A

endocrine

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13
Q

What is the funciton of hepatocytes?

A

make lots of shit adn release to space of disse– to sinudoid–> gets distributed

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14
Q

Describe Space of Disse

A

located btwn fenestreations adn hepatocytes

some stuf will get stuck in space of Disse and needs to get drained to lymph nodes

Contains stellate cells

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15
Q

What are stellate cells adn where are they located?

A

Responsible for collagen depostion–> fibrosis–> cirrhosis

In space of Disse

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16
Q

What is a hepactic acinus?

A

Has Zone 1: more virus and shit

zone 3: ischemic area

17
Q

• Mechanism for concentration:
absorption of____, ______ and _______,
leads to concentration of bile salts, cholesterol, lecithin and bilirubin

A

water, sodium and chloride

18
Q

• Cholesterol and
lecithin are solubilized by

• Volume goes from 500 ml to 50 ml

A

bile salts

19
Q

Funciton of Bile Salts:

how does it decrease surface tension?

how does it aid in digetsion of fats?

A

Emulsification

Forming micells

20
Q

Micells are made of

A

Fatty acids, monoglycerides, cholesterol

21
Q

Fatty foods in duodenum results in release of________
That causes gallbladder contraction and emptying in under 1 hour

22
Q

Two functions of CCK

A

gallbladder contraction and emptying in under 1 hour
o CCK also causes relaxation of the Sphincter of Oddi

23
Q

What is the role of secretin?

A

Increases HCO3- release from pancrease (decrease pH)

decrease gastric acid secreation

Increases bile secreation specifically at bile duct of HCO3-, Na+, H2O

24
Q

Increases pancreatic secreation, increases GB contraction, Incresas SOD relaxation, decreases gatsric emptying

A

CCK (regulated by FA in teh duodenum)

25
 Acts on biliary epithelium to produce a solution rich in sodium bicarbonate o Helps neutralize acids o Optimizes pancreatic function
secretin
26
Pancreatic secretions in response to chyme in upper small intestine with juice characteristics dependent on :
type of food
27
General anatomy of pancreas
appreciate it
28
What does the pancreatic acinus secreate? What about the pancreatic duct?
Acinus secreates digestive enzymes Duct secreates bicarb
29
What form is trypin secreated in? What enZ actviate trypsin?
 Secreted in inactive form: chymotrypsin, chymotrypsinogen and procarboxypolypeptidase
30
Proteins ----\> proteoses, peptone/polyepetides via what enZ?
Pepsin
31
Protesose, Peptonse, Polypepetides--\> Polypeptides +AA via What enZ?
trypsin, chymotrpysin, carbosypolpeptidase, protealse
32
• Majority of dietary fats are \_\_\_\_\_\_\_= Glycerol nucleus + 3 fatty acid side chains • Pancreatic lipase digests them w/in 1 min  Free fatty acids and 2-monoglycerid
triglycerides (TG)
33
Role of bile salts in fat digestion
Fat acted on by bile --\> emulsified fat emulsifed fat--\> pancreatic lipase--\> FA + 2 monoglycerides bile salts f**orm micelles** and remove monoglycerides and fatty acids and transport them to brush border for absorption
34
Key components of bicarb secreation
have Na adn HCO3- released into the lumen need to have carbonic anyhdrase helping out with resorbed CO2 and H2O This shit will neutralize acids so pancreatic enZ can work
35
•\_\_\_\_\_\_\_- acts on acini to produce digestive enzymes •\_\_\_\_\_\_\_- acts on pancreatic duct epithelium to produce bicarbonate-rich solution
Cholecystokinin Secretin