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Pharm Test 3 > Heparin & Oral Anticoagulants > Flashcards

Heparin & Oral Anticoagulants Flashcards

1
Q

Heparin Mech of Action

A

Complex w/ AT and inhibits factors Xa and IIa. Monitored by APTT.

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2
Q

Heparin Route of Administration

A

Mainly IV and also given subcutaneous

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3
Q

Heparin Indications

A

Mainly intravenous and also given subcutaneous

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3
Q

Heparin Indications

A

Surgical Antigcoagulation

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3
Q

Heparin Side Effects

A

Bleeding, HIT, osteoporosis, alopecia

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3
Q

Low Molecular Weight Heparins (Branded and Generic) Mech of Action

A

Complex with AT and inhibits factors Xa and IIa

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3
Q

Low Molecular Weight Heparins Route of Administration

A

Mainly subcutaneous

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4
Q

Low Molecular Weight Heparins Indications

A

Prophylaxis and treatment of DVT and ACS (acute coronary syndrome)

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5
Q

Low Molecular Weight Heparins Side Effects

A

Bleeding

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6
Q

Fondaparinux (Pentasaccharide) Mech of Action

A

Complex w/ AT and inhibits factor Xa

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7
Q

Fondaparinux (Pentasaccharide) Route of Administration

A

Subcutaneous

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8
Q

Fondaparinux (Pentasaccharide) Indications

A

Management of DVT

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9
Q

Fondaparinux (Pentasaccharide) Side Effects

A

Bleeding

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10
Q

Argatroban Mech of Action

A

Inhibits IIa

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11
Q

Argatroban Route of Administration

A

IV

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12
Q

Argatroban Indications

A

Anitcoagulant management of HIT patients

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13
Q

Argatroban Side Effects

A

Bleeding

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14
Q

Bivalirudin Mech of Action

A

Inhibits IIa

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15
Q

Bivalirudin Route of Administration

A

IV

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16
Q

Bivalirudin Indications

A

Anticoagulant management of HIT patients

17
Q

Bivalirudin Side Effects

A

Bleeding

18
Q

Hirudin Mech of Action

A

Inhibits IIa

19
Q

Hirudin Route of Administration

A

IV

20
Q

Hirudin Indications

A

Anticoagulant management of HIT patients

21
Q

Hirudin Side Effects

A

Bleeding

22
Q

Antithrombin Concentrate Mech of Action

A

Inhibits IIa

23
Q

Antithrombin Concentrate Route of Administration

A

IV

24
Q

Antithrombin Concentrate Indications

A

DIC
sepsis
thrombophilia
hypercoagulable state

25
Q

Antithrombin Concentrate Side Effects

A

none

26
Q

Protamine Sulfate Mech of Action

A

Heparin antagonist

27
Q

Protamine Sulfate Route of Administration

A

IV

28
Q

Protamine Sulfate Indications

A

reversal for Heparin

29
Q

Protamine Sulfate Side Effects

A

Bradycardia, hypotension

30
Q

Warfarin Mech of Action

A

Competitive antagonist of Vit K

Suppresses the synthesis of functional forms of factors II, VII, IX, and X

31
Q

Warfarin Monitoring

A

Prothrombin time/INR

32
Q

Warfarin Indications

A

Prolonged treatment of DVT and Atrial Fibrillation

33
Q

Warfarin Side Effects/Toxicity

A

Bleeding, coumadin induced necrosis

34
Q

Vitamin K Mech of Action

A

Cofactor in the synthesis of functional forms of factors II, VII, IX, and X

35
Q

Vitamin K Monitoring

A

not required

36
Q

Vitamin K Indications

A

Hypoprothrombinemia
intestinal disorders
gastrectomy

37
Q

Vitamin K Side Effects/Toxicity

A

Hemolysis

38
Q

Oral Anti-Xa: Mech of Action
Rivaroxaban
Apixaban

A

inhibits factor Xa

39
Q

Oral Anti-Xa: Monitoring
Rivaroxaban
Apixaban

A

not required

40
Q

Oral Anti-Xa: Indications
Rivaroxaban
Apixaban

A

prophylaxis of DVT

atrial fibrillation in the prevention of stroke

41
Q

Oral Anti-Xa: Side Effects/Toxicity
Rivaroxaban
Apixaban

A

Bleeding

liver toxicity

42
Q

Oral Antithrombin- Dabigatran Mech of Action

A

Inhibits thrombin

43
Q

Oral Antithrombin- Dabigatran Monitoring

A

not required

44
Q

Oral Antithrombin- Dabigatran Indications

A

prophylaxis of DVT

atrial fibriallation in the prevention of stroke

45
Q

Oral Antithrombin- Dabigatran Side Effects/Toxicity

A

Bleeding

liver toxicity

Pharm Test 3 (10 decks)

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