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Pharm Test 3 > Heparin & Oral Anticoagulants > Flashcards

Heparin & Oral Anticoagulants Flashcards

(49 cards)

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1
Q

Heparin Mech of Action

A

Complex w/ AT and inhibits factors Xa and IIa. Monitored by APTT.

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2
Q

Heparin Route of Administration

A

Mainly IV and also given subcutaneous

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3
Q

Heparin Indications

A

Mainly intravenous and also given subcutaneous

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3
Q

Heparin Indications

A

Surgical Antigcoagulation

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3
Q

Heparin Side Effects

A

Bleeding, HIT, osteoporosis, alopecia

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3
Q

Low Molecular Weight Heparins (Branded and Generic) Mech of Action

A

Complex with AT and inhibits factors Xa and IIa

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3
Q

Low Molecular Weight Heparins Route of Administration

A

Mainly subcutaneous

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4
Q

Low Molecular Weight Heparins Indications

A

Prophylaxis and treatment of DVT and ACS (acute coronary syndrome)

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5
Q

Low Molecular Weight Heparins Side Effects

A

Bleeding

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6
Q

Fondaparinux (Pentasaccharide) Mech of Action

A

Complex w/ AT and inhibits factor Xa

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7
Q

Fondaparinux (Pentasaccharide) Route of Administration

A

Subcutaneous

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8
Q

Fondaparinux (Pentasaccharide) Indications

A

Management of DVT

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9
Q

Fondaparinux (Pentasaccharide) Side Effects

A

Bleeding

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10
Q

Argatroban Mech of Action

A

Inhibits IIa

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11
Q

Argatroban Route of Administration

A

IV

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12
Q

Argatroban Indications

A

Anitcoagulant management of HIT patients

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13
Q

Argatroban Side Effects

A

Bleeding

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14
Q

Bivalirudin Mech of Action

A

Inhibits IIa

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15
Q

Bivalirudin Route of Administration

A

IV

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16
Q

Bivalirudin Indications

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A

Anticoagulant management of HIT patients

17
Q

Bivalirudin Side Effects

18
Q

Hirudin Mech of Action

19
Q

Hirudin Route of Administration

20
Q

Hirudin Indications

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A

Anticoagulant management of HIT patients

21
Hirudin Side Effects
Bleeding
22
Antithrombin Concentrate Mech of Action
Inhibits IIa
23
Antithrombin Concentrate Route of Administration
IV
24
Antithrombin Concentrate Indications
DIC sepsis thrombophilia hypercoagulable state
25
Antithrombin Concentrate Side Effects
none
26
Protamine Sulfate Mech of Action
Heparin antagonist
27
Protamine Sulfate Route of Administration
IV
28
Protamine Sulfate Indications
reversal for Heparin
29
Protamine Sulfate Side Effects
Bradycardia, hypotension
30
Warfarin Mech of Action
Competitive antagonist of Vit K Suppresses the synthesis of functional forms of factors II, VII, IX, and X
31
Warfarin Monitoring
Prothrombin time/INR
32
Warfarin Indications
Prolonged treatment of DVT and Atrial Fibrillation
33
Warfarin Side Effects/Toxicity
Bleeding, coumadin induced necrosis
34
Vitamin K Mech of Action
Cofactor in the synthesis of functional forms of factors II, VII, IX, and X
35
Vitamin K Monitoring
not required
36
Vitamin K Indications
Hypoprothrombinemia intestinal disorders gastrectomy
37
Vitamin K Side Effects/Toxicity
Hemolysis
38
Oral Anti-Xa: Mech of Action Rivaroxaban Apixaban
inhibits factor Xa
39
Oral Anti-Xa: Monitoring Rivaroxaban Apixaban
not required
40
Oral Anti-Xa: Indications Rivaroxaban Apixaban
prophylaxis of DVT | atrial fibrillation in the prevention of stroke
41
Oral Anti-Xa: Side Effects/Toxicity Rivaroxaban Apixaban
Bleeding | liver toxicity
42
Oral Antithrombin- Dabigatran Mech of Action
Inhibits thrombin
43
Oral Antithrombin- Dabigatran Monitoring
not required
44
Oral Antithrombin- Dabigatran Indications
prophylaxis of DVT | atrial fibriallation in the prevention of stroke
45
Oral Antithrombin- Dabigatran Side Effects/Toxicity
Bleeding | liver toxicity

Pharm Test 3 (10 decks)

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