henoch schonlein purpura

Question 1

What is the most common vasculitis in children?

Answer 1

Henoch-Schonlein Purpura

Question 2

What type of vasculitis is Henoch-Schonlein Purpura ?

Answer 2

IgA

Question 3

What are the triggers of Henoch-Schonlein Purpura ?

Answer 3

MAFIC (almost the same as for LCV MANIC, but replace NSAIDS with Food)

• Medications
• autoimmune condtions
• foods (blue cheese)
• infections
• cancer

Question 4

What is classic tetrad of Henoch-Schonlein purpura?

Answer 4

1. palpable purpura of legs and butt
2. arthralgia of knees and ankles
3. GI issues (abdominal pain and diarrhea w/ or w/o bleeding
4. renal changes: hematuria, possible nephritis, renal failure in 1% of cases

Question 5

What percent of cases of Henoch-Schonlein purpura can have renal failure?

Answer 5

about 1%

Question 6

What types of cancers are a/w Henoch-Schonlein purpura?

Answer 6

solid organ and hematologic

Question 7

What are the risk factors for renal involvement with Henoch-Schonlein purpura in adults?

Answer 7

1. purpura above the waist (“closer to kidneys”)
2. fevers
3. elevated ESR

Question 8

Histology and DIF of Henoch-Schonlein purpura:

Answer 8

histology is same as LCV (because it is a small vessel vasculitis)

• DIF with IgA in blood vessel walls

Question 9

Treatment for Henoch-Schonlein purpura:

Answer 9

supportive

• can use prednisone or dapsone
• monitor with serial UA’s and stool guac if GI symptoms

Question 10

Serial lab monitoring for patients with Henoch-Schonlein purpura includes:

Answer 10

serial UA’s and stool guiacs (if GI involvement)