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Lab Med 2.0 > Hemostasis/WBC/Anticoag > Flashcards

Hemostasis/WBC/Anticoag Flashcards

1
Q

Platelet Plug

A
  1. Plts adhere to vWF through GPIb
  2. Plts adhere to collagen through GPIa
  3. Plts aggregate when GPLLb binds to fibrinogen after plts are activated (CAT)
  4. Act plts secrete ADP and thromboxane = vasoconstriction and factor Va

WCAFAT

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2
Q

Coag Cascade: Form a fibrin clot

A
  1. Endo makes TF
  2. TF activates VII
  3. VIIa activates X and IX
  4. II (pro) to IIa (thrombin)
  5. IIa makes fibrinogen into fibrin
  6. XIII crosslinks to make stable clot

T 7 910 2 2a F 13

TSNTTTFT

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3
Q

Prothrombin Time

A

-Time for conversion of prothrombin to thrombin
-VII dependent paths
-Performed by adding TF to plasma
-Often converted to INR (2-3)
-Best for Coumadin therapy

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4
Q

APTT

A

-Time to form clot
-Evaluates XII dependent paths
-Exposing blood to negative charged surface
-Best for Heparin therapy
-Screen for hemophilia A/B

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5
Q

Heparin

A

-Requires ATIII
-Inhibits thrombin (II), X primarily

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6
Q

Warfarin

A

-Antagonist of VK
-Inhibits II, VII, IX, and X (and C/S)

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7
Q

Factor Xa Inhibitors

A

-Riva, apixa, edoxa
-Safer than warfarin
-Dabi is direct thrombin inhibitor

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8
Q

Streptokinase

A

-Forms non-covalent attachment with plasminogen = free plasmin = digests fibrin clots

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9
Q

TPA

A

-Activates plasminogen bound to fibrin
-Reteplase is deletion mutant of TPA

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10
Q

Aspirin

A

-Prevent formation of thromboxane A2

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11
Q

Clopidogrel

A

-Blocks purine receptor
-May cause TTP

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12
Q

Abciximab

A

MAB against IIb/IIIa receptors

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13
Q

Platelets

A

-Increase in inflammation, disseminated cancer

-Decrease in ITP, TTP, bone marrow failure, DIC

place CI TI BD

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14
Q

White Blood Cells

A

-Increase in infection, inflammation

-Decrease in aplastic anemia (do not recover), hypoplastic anemia (recover)

IIAHA

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15
Q

Neutrophils

A

Increase in steroid use, inflammation (bacteria infection)

ISI is neutral

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16
Q

Lymphocytes

A

-Increase in viral infections

-Decrease in steroid use, immune dificiency

VI SID

17
Q

Neutropenia, Lymphopenia, Thrombocytopenia are often ___

A

Drug-induced
-One cell line decreased = drug induced
-All cells decreased = stem cell problem (disease or drug induced)

18
Q

Change in White Cell Count after Steroids

A

-Increase in neutrophils, platelets

-Decrease in lymphocytes, eosinophils, basophils

NP BEL

Lab Med 2.0 (20 decks)

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