Hemostasis basics Flashcards
Hemostasis
Stoppage of bleeding
hemostasis in small vessels vs large vessels
most effective in small vessels
body usually can’t control bleeding from medium/large artery
venous bleeding
less rapid blood loss due to low BP
raising the bleeding part above heart level (increasing hydrostatic pressure) may stop haemorrhage
internal venous bleeding causing blood accumulation in tissues may interstitial pressure enough to eliminate pressure gradient for blood loss
hematoma
accumulation of blood in tissue
any vessel type
vessel’s inherent response to damage or severance
constriction
changes in local vasodilator and constrictor substances released by endothelial and blood cells
constriction presses endothelial walls together
substances released by endothelial/blood cells
local vasodilator and constrictor substances
change during constriction induced by vessel damage
permanent closure of vessel by constriction
occurs only in smallest vessels of microcirculation
factors affecting staunching of bleeding
formation of a platelet plug
blood coagulation