Hemostasis Antovoagulant Flashcards
Indication of anticoagulant drugs administration
Venous thrombosis prevention
Deep vein thrombosis
Postoperative thrombosis prevention Pulmonary embolism
Nonvalvular atrial fibrillation Artificial valve
Cardioembolic ischemic stroke
Coagulation mechanism only 3 phase ? ( imp for ashooriano roli )
Whar is the main molecule in 1st and 2nd phases ?
Vascular endothel
Cellular platelet (tjombocyte)
Humoral coagaulation ohase
Cascade kollesh
Pas anti thrombin 3 rooye … be … tasir manfi dare k fibrin tashkil nashe
Parenteral anti coagulant … and …
ADA RW
Heparin and LMWH function is … with half life of … their antidote is … and antidoge dosage is … .
Note: here half life is ORALLY (parenteral )
Question:
Here is orally why iv im zade ?
Fekonam javabo peyda ksrdam chon oon protamin szulfate va deug nist
Enhances the effect of Antithrombin III (Activate antithrombin3 so deactivr thromib
Va factor Xa
24h
Antidote: protamin-szulfát iv./im
Antidote: protamin-szulfát iv./1mg protamin-szulfát / 1mg enoxaparin,
Heparin injection by …
Half life is …
Monitoring is …
Antidoge is …
For dialis patient ?
iv./sc. injekció
Half life: 30-120 min
Monitoring: APTT Antidote: protamin-szulfát
Dialysis patients: We plan the intervention on the day after the dialysis.
Intervention should be carried out before dialysis/getting injection.
AB profilaxis!!
Heparin may have allergy and …
Rebound
Active agent of LMWH ?
Enoxaparin (Clexane, Levonox, Xaparin),
Nadroparin (Fraxiparine), Bemiparin, Reviparin, Parnaparin, Certoparin, Dalteparin, Tinzaparin
Te teenage bood mamehash mesle dall bod
(Tin dalte)pas ta inja ye porn darin (parna)
Bayad bemire (bemi revi )
LMWH
Injection is … antidote … monitoring … half life ?
sc./iv. injekció
Antidote: protamin-szulfát Monitoring: anti-Xa test
Half life: 8-10 óra
(8 ta 10 shab dire LATE night
Low Mwh ) (low ta late yeli)
Axo bebein inam anti Xa
ORAL anticoagulant ?
Acenocoumarol (Syncumar) Warfarin (Marfarin)
Dabigatran (Pradaxa)
Rivaroxaban (Xarelto),
Apixaban (Eliquis)
Syncumar warfarin ?
Bridging ?
Suspension or replacement of long-term anticoagulant treatment with fast acting anticoagulants
10-12 days long procedure
Bridging for 3 days before naf 4-10 days after ?
New genertion od
1-Rivaroxaban (Xarelto)
google :under name
prevent clot
Specially deep vein thrombosis
2-Apixaban (Eliquis)
3-Dabigatran (Pradaxa)
Cascade daghigh tar ?
Rivaroxa , and apixaban ihibite …
Xa
Age 10 faal bega bere bad 10 va 5 az tye taraf va 9 va 8 az te taraf nemitoonan prothrombino konan thrombon 2 to 2a
Dibagatran function ?
Local hemostasis
