Hemostasis Flashcards
Cite the stages of hemostasis
- Vascular constriction
- Platelet plug formation
- Fibrin formation
- Fibrinolysis
What are the clotting factors for the extrinsic pathway ONLY
Factor VII
[Stages of Hemostasis]
___ refers to platelet plug formation and aggregation
primary hemostasis
[Stages of Hemostasis]
What glycoprotein plays a role in platelet adhesion?
GP Ib
[Stages of Hemostasis]
Deficiency in GP Ib is called
bernard soulier syndrome
[Stages of Hemostasis]
What glycoprotein plays a role in platelet aggregation?
GP IIb/IIIa
deficiency in GP IIb/IIIa is called?
Glanzman Thrombastenia
[Stages of Hemostasis]
GPIb attaches to this factor during platelet adhesion
vWF
[Stages of Hemostasis]
___ deposition of insoluble fibrin generated by the coagulation cascade
secondary hemostasis
[Stages of Hemostasis]
what are the coagulation factors in the common pathway?
II V X
2 x 5 = 10
hemorrhage is associated with ___ (acidosis/alkalosis)
acidosis
what drug inhibits platelet aggregation?
aspirin
What is the treatment of choice for patients with vWF disease?
Factor VIII
or DDAVP
[blood transfusion]
if the blood loss is up to 20% of total blood volume, that will be the replacement choice?
crystalloid
[blood transfusion]
if the blood loss is more than 20% of total blood volume, that will be the replacement choice?
pRBC + FFP
[blood transfusion]
In massive transfusion, that is the anticipated number of units of pRBC in 24 hours
> / 10 units
[blood transfusion]
what is the ratio of plasma, platelets and RBCs during massive transfusion
1:1:1
[blood transfusion]
patient developed immediate transfusion reaction. Diuresis was initated.
what will you do to the urine? Alkalinize/Acidify?
Alkalinize
[transfusion complication]
(+)fever
preformed cytokines; host Ab to donor lymphocytes
febrile, nonhemolytic transfusion reaction
[transfusion complication]
infusion of contaminated blood
(+) fever, chills, hemodynamic changes
Non-hemolytic bacterial contamination
[transfusion complication]
soluble transfusion constituents are implicated
Rash, hives, itching
NHTR, allergic reactions
[transfusion complication]
large volume of blood transfused into an older patient with CHF
Transfusion Associated Circulatory overload
[transfusion complication]
Anti-HLA or anti-HNA Ab in transfused blood attacks circulatory and pulmonary leukocytes
Transfusion related acute lung injury
[transfusion complication]
Transfusion of ABO incompatible blood; preformed IgM Ab to ABO Ag
Hemolytic reaction, acute
[transfusion complication]
IgG mediated
Low haptoglobin level
positive direct coombs test
hemolytic reaction, delayed type
[diagnose]
decreased platelets
normal blood clot lysis time
protamine test positive
DIC
[diagnose[
normal platelets
negative protamine test
decreased clot lysis time
Primary fibrinolysis
What is the antidote for rivaroxaban and apixaban?
Andexanet Alfa
What is the antidote for dabigatran and Argatroban
Idaruximab
What drug inhibits antithrombin III
Fondaparinoux
