Hemostasis

Question 1

Cite the stages of hemostasis

Answer 1

1. Vascular constriction
2. Platelet plug formation
3. Fibrin formation
4. Fibrinolysis

Question 2

What are the clotting factors for the extrinsic pathway ONLY

Answer 2

Factor VII

Question 3

[Stages of Hemostasis]

___ refers to platelet plug formation and aggregation

Answer 3

primary hemostasis

Question 4

[Stages of Hemostasis]

What glycoprotein plays a role in platelet adhesion?

Answer 4

GP Ib

Question 5

[Stages of Hemostasis]

Deficiency in GP Ib is called

Answer 5

bernard soulier syndrome

Question 6

[Stages of Hemostasis]

What glycoprotein plays a role in platelet aggregation?

Answer 6

GP IIb/IIIa

Question 7

deficiency in GP IIb/IIIa is called?

Answer 7

Glanzman Thrombastenia

Question 8

[Stages of Hemostasis]

GPIb attaches to this factor during platelet adhesion

Answer 8

vWF

Question 9

[Stages of Hemostasis]

___ deposition of insoluble fibrin generated by the coagulation cascade

Answer 9

secondary hemostasis

Question 10

[Stages of Hemostasis]

what are the coagulation factors in the common pathway?

Answer 10

II V X

2 x 5 = 10

Question 11

hemorrhage is associated with ___ (acidosis/alkalosis)

Answer 11

acidosis

Question 12

what drug inhibits platelet aggregation?

Answer 12

aspirin

Question 13

What is the treatment of choice for patients with vWF disease?

Answer 13

Factor VIII

or DDAVP

Question 14

[blood transfusion]

if the blood loss is up to 20% of total blood volume, that will be the replacement choice?

Answer 14

crystalloid

Question 15

[blood transfusion]

if the blood loss is more than 20% of total blood volume, that will be the replacement choice?

Answer 15

pRBC + FFP

Question 16

[blood transfusion]

In massive transfusion, that is the anticipated number of units of pRBC in 24 hours

Answer 16

> / 10 units

Question 17

[blood transfusion]

what is the ratio of plasma, platelets and RBCs during massive transfusion

Answer 17

1:1:1

Question 18

[blood transfusion]

patient developed immediate transfusion reaction. Diuresis was initated.

what will you do to the urine? Alkalinize/Acidify?

Answer 18

Alkalinize

Question 19

[transfusion complication]

(+)fever

preformed cytokines; host Ab to donor lymphocytes

Answer 19

febrile, nonhemolytic transfusion reaction

Question 20

[transfusion complication]

infusion of contaminated blood

(+) fever, chills, hemodynamic changes

Answer 20

Non-hemolytic bacterial contamination

Question 21

[transfusion complication]

soluble transfusion constituents are implicated

Rash, hives, itching

Answer 21

NHTR, allergic reactions

Question 22

[transfusion complication]

large volume of blood transfused into an older patient with CHF

Answer 22

Transfusion Associated Circulatory overload

Question 23

[transfusion complication]

Anti-HLA or anti-HNA Ab in transfused blood attacks circulatory and pulmonary leukocytes

Answer 23

Transfusion related acute lung injury

Question 24

[transfusion complication]

Transfusion of ABO incompatible blood; preformed IgM Ab to ABO Ag

Answer 24

Hemolytic reaction, acute

Question 25

[transfusion complication]

IgG mediated

Low haptoglobin level

positive direct coombs test

Answer 25

hemolytic reaction, delayed type

Question 26

[diagnose]

decreased platelets
normal blood clot lysis time
protamine test positive

Answer 26

DIC

Question 27

[diagnose[

normal platelets
negative protamine test
decreased clot lysis time

Answer 27

Primary fibrinolysis

Question 28

What is the antidote for rivaroxaban and apixaban?

Answer 28

Andexanet Alfa

Question 29

What is the antidote for dabigatran and Argatroban

Answer 29

Idaruximab

Question 30

What drug inhibits antithrombin III

Answer 30

Fondaparinoux