Hemostasis

Question 1

GPIb

Answer 1

Enables plts to bind to vWF, plt aggregation, ass. wBernard-Soulier syndrome

Question 2

GPIIb/IIIa

Answer 2

Enables plt adhesion, Glanzmans thrombathenia

Question 3

Hypercoagulable states

Answer 3

DVT, malignancy, lupus anticoagulant, Factor V Leiden

Question 4

Low plt, decreased ristocetin cofactor, abnormal plt function

Answer 4

Bernard-Solier

Question 5

Normal plt count, normal ristocetin cofactor, abnormal plt function

Answer 5

Glanzmans Thrombasthenia

Question 6

Normal plt count, abnormal aPTT, normal PT,

Answer 6

Factor VIII deficiency, hemophilia A

Question 7

Normal plt, high PFA, decreased ristocetin cofactor, prolonged to normal aPTT

Answer 7

Von Willebrand’s disease

Question 8

Warfarin/Coumadin

Answer 8

monitor with PT, prevent carboxylation of vit K, reverse with vit K,

Question 9

Vit K-dependent factors

Answer 9

cannot bind Ca++ without Vit K, 1972, 10, 9 ,7, 2, protein C, protein s

Question 10

Heparin

Answer 10

Enhances cofactor for anti-thrombin, in hibits 9,10,11,2, monitor with aPTT, reverse with protamine sulfate

Question 11

PTT

Answer 11

<45sec, plasma +calcium+Kaolin+phospholipids, intrinsic

Question 11

PT

Answer 11

<15sec, plasma+calcium+ tissue thromboplastin, extrinsic

Question 12

PT prolonged aPTT normal

Answer 12

VII deficiency, warfarin,

Question 13

PT normal aPTT prolonged

Answer 13

VIII (hemophilia A) , IX (hemophilia B), XI, XII deficiency, VIII inhibitor, vWD

Question 14

aPTT prolonged, PT prolonged

Answer 14

I, II, V, X deficiency,

Question 15

Lupus anticoagulant

Answer 15

Prolong aPTT, hypercoagulation, corrected with plt neutralization

Question 16

Correction of PT and aPTT at 0 ant 90 min

Answer 16

factor deficiency

Question 17

Correction of PT and aPTT at 90 min only

Answer 17

inhibitor dependent on time/temp

Question 18

aPTT normal PT normal, significant bleeding/poor wound healing

Answer 18

XIII deficiency, confirmed with 5M urea test

Question 19

Hemophilai B treatment

Answer 19

IX concentrates

Question 20

vWF Disease Treatment

Answer 20

DDVAP, cryo, Humate P (VIII+vWF)

Question 21

TTP treatment

Answer 21

Plasmapheresis

Question 22

ITP Treatment

Answer 22

Steroids, IVIG, plt transfusion and splenectomy last resort

Question 23

Hemophilia A Treatment

Answer 23

Recombinate FVIII, prothrombin complex, FFP, Cryo

Question 24

Factor V leiden

Answer 24

Mutant factor 5, resists inhibitor action of protein C and protein S

Question 25

Liver disease

Answer 25

Factor I, II, V, VII, IX, X deficiencies, (VII most pronounced, shortest half life)

Question 26

Intrinsic

Answer 26

XII, XI, IX, VIII, X (12,11,9,8,10)

Question 27

Extrinsic

Answer 27

TF(III), VII, X

Question 28

Common

Answer 28

X, prothrombin (II), thrombin (IIa), fibrinogen(I), fibrin(Ia), XIII, CA2+, Factor 5 cofactor, plt phosphlipid.