Hemorrhoids, Diarrhea, Gas Flashcards

1
Q

Hemorrhoids: Definition & Symptoms

A
• Enlargement or inflammation of normal structures
• Mild symptoms: 
– Itching
– Irritation
– Burning
– Swelling
– Inflammation
• Severe symptoms: 
- Pain
- Bleeding
- Seepage
- Thrombosis 
- Prolapse
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Diarrhea: Definition & Symptoms

A

• Stool frequency or liquidity greater than normal
– “Normal” varies from patient to patient
– May be associated with urgency, pain, flatulence
• Patient reports:
– The runs
– The trots
– La turista

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Gas: Symptoms

A
• Belching
• Flatus
• Cramping or distension
• Excessive quantity, foul odor, or causing pain 
– Excessive flatus: >20 passages/day
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hemorrhoids: Activities & Conditions

A
• From pressure, irritation, or weakness of anal tissue
– Behaviors & activities 
• Heavy lifting
• Prolonged standing 
• Erect posture
• Straining
- Other conditions 
• Advanced age
• Heredity
• Diarrhea
• Constipation 
• Pregnancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Diarrhea: Infections & Medications

A
• From increased gut motility, secretion, or osmolarity
– Infections
• Viral (most common)
• Bacterial 
• Protozoal 
• Toxins
– Food intolerance
• Enzyme deficiency
- Medications 
• Antibiotics
• Laxatives 
• Stimulants
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Gas: Belching & Flatus

A

• Belching: Mostly from swallowed air
– Carbonated drinks
– Chewing gum
– Smoking
– Other (psychiatric)
• Flatus: Mostly from gut bacterial metabolism
– Maldigestion of certain foods (lactose, fiber, etc)
– Bacterial overgrowth (caused by certain drugs or diseases)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hemorrhoids: Referral Criteria

A

Severe symptoms

  • Pain
  • Bleeding
  • Prolapse
  • Seepage
  • Thrombosis
  • OTC treatment failure (> 7 days)

High risk patients

  • Children < 12 yo
  • History of GI disease
  • Family history of colon cancer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Diarrhea: Referral Criteria

A

Severe dehydration

  • Dizziness
  • Lethargy
  • Confusion
  • Low blood pressure
  • Tachycardia
  • Decreased urination

Systemic illness

  • Fever
  • Severe pain
  • Blood or pus in stool
  • Prolonged vomiting
  • OTC treatment failure (> 2 days)

High risk patients

  • Infants < 6 months
  • Pregnancy
  • Diabetes
  • Kidney disease
  • Heart disease
  • Immunosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Gas: Referral Criteria

A

Severe symptoms

  • Pain
  • Frequency
  • Duration

Signs of another problem

  • Other accompanying symptoms: fatigue, weight loss, bleeding
  • Sudden changes in symptoms: bowel habits, pain location, frequency or duration, new onset if age > 40 yo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hemorrhoids: Non-Pharmacologic Treatment

A

• Bowel modifications
– Act on the urge (don’t hold it in)
– Limit sitting time, don’t strain – Anal hygiene

• Dietary modifications
– Increase fiber
– Increase fluids

• Non-pharmacologic treatments
– Sitz baths
– Surgery (laser, banding, sclerosis, etc)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Diarrhea: Non-Pharmacologic Treatment

A

• Maintain healthy diet
– Complex carbs & Protein
– Avoid: High fat, sugar, spice, or caffeine content
– Not recommended: “BRAT diet” (bananas, rice, applesauce, toast), bowel rest

• Prevention
– Sanitation (hand washing, food handling)
– Avoid sick contacts

• Fluid & electrolyte replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Diarrhea: Oral Rehydration

A

• Solutions of sodium and glucose are most effective (Pedialyte)

  • NaCl = 2.6 g/L
  • Glucose = 13.5 g/L
  • KCl = 1.5 g/L
  • Sodium citrate = 2.9 g/L

• Immediate treatment: 2-4 L over 4 hours
– Children ≤ 5yo: 50-100 mL/kg over 4 hours

• Maintenance: As needed to replace ongoing losses
– Children ≤ 5yo: 10 mL/kg or 1⁄2 - 1 cup per loose stool

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Gas: Non-Pharmacologic Treatment

A

• Behavioral modifications
– Eat slowly, don’t gulp air
– Mild exercise after meals

• Dietary modifications
– Avoid carbonated drinks, gum
– Decrease carbohydrates (beans, starch, lactose, fiber)

• Bowel modifications
– Avoid constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hemorrhoids: OTC, external vs. internal use

A
  • Local anesthetics (Lidocaine, pramoxine): External only
  • Astringents: External only
  • Keratolytics: External only
  • Analgesics (Witch hazel): External only
  • Corticosteroids (Hydrocortisone): Both
  • Vasoconstrictors (Phenylephrine): Both
  • Protectants (Glycerin, petrolatum, mineral oil, cocoa butter): Both
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hemorrhoids: OTC MOA

A
  • Local anesthetics
    Block nerve transmission, ↓ all sensation
  • Vasoconstrictors
    Less blood flow, ↓ swelling
  • Protectants
    Protective barrier, ↓ irritation from stool
  • Astringents
    Dries skin, ↓ itch, gives some protection
  • Keratolytics
    Removal of epidermal surface cells
  • Analgesics
    Heat / cold / tingling, soothing sensations
  • Corticosteroids
    Decrease itch & inflammation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Hemorrhoids: OTC Adverse Effects

A
  • Local anesthetics
    Allergy, contact dermatitis
  • Vasoconstrictors
    HTN, heart disease, urinary retention
  • Protectants
    Rare, poorly absorbed
  • Astringents
    Irritation, contact dermatitis
  • Keratolytics
    Resorcinol: circulatory failure
  • Analgesics
    Irritation, central nervous effects
  • Corticosteroids
    Skin atrophy, ↑ risk of infec􏰃on
17
Q

Hemorrhoids: OTC Max Dosing

A
  • Local anesthetics: 6x (pramoxine: 5x) (dibucaine: 4x)
  • Vasoconstrictors: 4x
  • Protectants: 6x, or after each bowel movement
  • Astringents: 6x, or after each bowel movement
  • Keratolytics: 6x
  • Analgesics: 6x
  • Corticosteroids: 3-4x
18
Q

Diarrhea: MOA

A

Loperamide
- Decreases intestinal motility and secretion

Bismuth subsalicylate

  • Bismuth -> Antibacterial
  • Salicylate -> Antisecretory
19
Q

Loperamide: Use & AEs

A

• Use: Acute treatment of diarrhea in adults & children
– Decreases stool frequency, volume, and liquidity

• AE’s: Rare (low systemic absorption)
– Abdominal pain, constipation, paralytic ileus
– Risk of arrhythmias if max doses are exceeded (abuse)
– May worsen underlying infections

• Practical issues:
– Adults: 4mg x1, then 2mg q loose stool (Max 8 mg/day OTC)
– 9-11yo: 2mg x1, then 1mg q loose stool (Max 6 mg/day)
– 6-8yo: (Max 4mg/day)

20
Q

Bismuth Subsalicylate

A

• Uses: Acute treatment of diarrhea in adults > 12 yo
– Treatment of nausea or upset stomach
– Prevention of travelers’ diarrhea

• AE’s:
– Black stained stools & tongue (harmless)
– Salicylate toxicity: tinnitus, Reye’s syndrome in children
– Bismuth toxicity: encephalopathy

• Practical issues:
– Decreased absorption of some antibiotics
– Available in tablets, capsules, and liquid formulations
– Dosing: 525mg q1h prn (Max 4200 mg/day = 8 doses/day)

21
Q

Diarrhea: Other Options

A

• Enzyme supplementation (Lactase)
– For diarrhea associated with dairy foods

• Adsorbents (kaolin, pectin, attapulgite)
– Used once upon a time
– Most are no longer recommended or available in the USA

22
Q

Gas: MOA

A
  • Simethicone: Decreases gas bubble surface tension
  • Lactase: Breaks down lactose into simpler sugars
  • α-galactosidase: Breaks down some 3-5 saccharides into simpler sugars
23
Q

Simethicone: Use & AEs

A

• Use: Relief of gas pain or bloating

• AE’s: Rare (not absorbed systemically)
– May increase flatus or belching

• Practical issues:
– Available as tablet, suspension, & combo products
– Adult dosing: 40 – 360 mg QID prn (Max 500mg/day)

24
Q

Lactase: Use & AEs

A
  • Use: Prevention of gas from dairy foods
  • AE’s: Rare (not systemically absorbed)

• Practical issues:
– Adult dosing: 3000-9000 units with 1st bite of lactose- containing food (Max 18,000 units/day)

25
Q

α-galactosidase: Use & AEs

A

• Use: Prevention of gas from high-fiber foods

• AE’s: Rare (not systemically absorbed)
– Mold allergy (enzyme is derived from mold)
– Diabetes (enzyme may increase sugar absorption)

• Practical Issues:
– Chewtab: 2-3 tabs/meal (based on number of food items)
– Solutab: 1 tab/meal

26
Q

Gas: Other Options

A

• Probiotics
– May help some patients if used long-term
– Slowest onset and weakest efficacy data
– Many products, usual dose is 1 capsule daily

• Activated charcoal
– Used once upon a time. No longer recommended due to very poor tolerability and side effects.