Hemolytic Disease Of Newborn

Question 1

Red Cell Membrane Defects manifest themselves in neonates in neonatal period..?

Answer 1

hereditary spherocytosis,
elliptocytosis,
stomatocytosis, and
infantile pyknocytosis

Question 2

Diagnosis of HS in newborn suggestive of..?

Answer 2

An elevated mean corpuscular hemoglobin concentration (MCHC >36.5–37 g/dL) or

MCHC to mean corpuscular volume (MCV) ratio (MCHC/ MCV >0.36

Question 3

T he two most common red cell enzyme defects that can lead to hyperbilirubinemia in the neonatal period are

Answer 3

G6PD

pyruvate kinase deficiency

Question 4

Reason for limited ability to concentrate urine due to limited urea concentration