HEMOGLOBIN

Question 1

identified the respiratory hemoglobin

Answer 1

Felix Seyler in 1862

Question 2

discovered the characteristics color spectrum of hemoglobin
proved that this was a true coloring matter of the blood

Answer 2

Felix Seyler in 1862

Question 3

first protein whose structure was described using ___________

Answer 3

X ray crystallography

Question 4

transport oxygen from ___________

Answer 4

lungs to tissues

Question 5

transport carbon dioxide from

Answer 5

tissues to lungs for exhalation

Question 6

contributes acid-base balance

Answer 6

by binding and releasing hydrogen ions and transport nitric oxide

Question 7

__________ of cytoplasmic RBC content

Answer 7

95%

Question 8

1 RBC contain approx ________

Answer 8

270 biomoleules of hemoglobin

Question 9

1 hemoglobin can carry _______

Answer 9

4 oxygen molecules

Question 10

________ provides protection to the hgb

Answer 10

RBC

Question 11

Molecule weight is approx _______

Answer 11

64,000 daltons

Question 12

the concentration of hemoglobin within RBCs is approximately ________

Answer 12

34/gdl

Question 13

usually referred to as being a ____________

Answer 13

tetrahedral structure

Question 14

make up of four subunits each containing a _____ and ________

Answer 14

heme group and polypeptide chain

Question 15

described to be a protein with a ____________

Answer 15

very complex structure

Question 16

hemoglobin structure

Heme - _______ + ________
Globin - ____________

Answer 16

iron + protoporphyrin
polypeptide chain

• alpha and beta chain

Question 17

globin portion

Answer 17

2 alpha and 2 beta chains

Question 18

heme portion

Answer 18

iron
protoporphyrin ring

Question 19

hemoglobin structure

contains __________
__________________ of ferrous iron
ferrous iron combines with _____________

Answer 19

contains protoporphyrin IX
central atom of ferrous iron
ferrous iron combines with one oxygen molecule

Question 20

heme biosynthesis occurs in the ____________ and ________________ beginning with the _____________ through the circulation of ____________

Answer 20

mitochondria and cytoplasm of bone marrow
pronormoblast and polychromatic

Question 21

heme biosynthesis occurs in most cells except for _________________

Answer 21

mature erythrocytes

Question 22

________________ are most predominant heme

Answer 22

red bone marrow and liver

Question 23

occurs in the mitochondria and cytoplasm Bm

Answer 23

heme biosynthesis

Question 24

______________ - initial reaction and last three steps

Answer 24

mitochondria

Question 25

intermediate or 4 steps

Answer 25

cytoplasm

Question 26

___________ do not have mitochondria and can’t make heme

Answer 26

mature rbcs

Question 27

___________ provide unique DNA codes for each globin type.

Answer 27

chromosome 11 and 16

Question 28

chains are designated by 7 greek letters

Answer 28

Alpha
beta
gamma
delta
epsilon
zeta
theta

Question 29

____________ has a positive charge

Answer 29

alpha chain

Question 30

has the highest affinity for beta chain due to its negative charge

Answer 30

alpha charge

Question 31

________________ has the next highest affinity

Answer 31

gamma globin chain

Question 32

next to gamma globin

Answer 32

delta globin chain

Question 33

two heterodimers then combine to form a tetramer

Answer 33

globin

Question 34

alpha has _________ amino acids

Answer 34

141

Question 35

beta, elta, gamma, epsilo, andz eta have amino acids of ______

Answer 35

146

Question 36

theta have __________ amino acids

Answer 36

unkown

Question 37

2 zeta + 2 epsilon

Answer 37

gower 1

Question 38

2 zeta + gamma

Answer 38

portland