Hemodynamics Flashcards
circulatory system is
closed
CO =
5 L/min
pressure gradient is created by
heart
RA pressure =
0 mmHg
flow occurs from ___ to ___ pressure
high to low
circulatory system is comprised of
heart - arteries- arterioles- capillaries - venules - veins- back to heart
flow is created by
pressure gradient
capacitance vessels
veins
blood makeup
plasma = water, protein
RBC, WBC, platelets
hematocrit
% of RBC in blood
flow regulating mechanisms
CO, cardiac function, tone + elasticity of vessels, interconnecting arterioles
principle point of resistance
interconnecting arterioles
regulators
interconnecting arterioles
vasomotor tone
constriction, dilation of vessels
Starlings law
stretch - > force of contraction of ventricles
HR is affected by
baroreceptors, chemoreceptors, exercise
Windkessel effect
elasticity of vessel, wall compliance, tone
reflection of wave back up vessel wall, creates dicrotic notch
arterial pulse pressure wave
pressure wave is propagated throughout arterial tree with each contraction of heart.
pressure wave velocity increases as it moves into smaller, stiffer peripheral arterioles
times it takes for pressure wave to travel from heart to foot
250 ms
arterial pulse pressure wave occurs in
vessel wall, independent of blood
volume flow
volume of blood passing a point per unit of time
adult blood flow rate
5 L/min
Q =
(A) X (TAV)
Continuity rule
volume in closed system must stay constant. Blood volume is not lost or created (conservation of matter)
Continuity rule in case of stenosis
since the same volume of blood must pass, but the area is smaller, the velocity therefore must increase
Continuity equation
A1V1 = A2V2
if area is halved, then velocity is
doubled
a change in area affects
pressure and flow
density of blood
1.05 g/mL
viscosity of blood
0.035 poise
viscosity is created by
internal frictional forces within the fluid
viscosity of blood is affected by
hypothermia, polycythemia, severe anemia
Q =
delta P/ R
if resistance increases, Q ____
decreases
if pressure gradient increases, Q ____
increases
Poiseuille’s law
describes flow through a tube
Poiseuille’s law states that flow is related to
viscosity, radius, length, pressure gradient
greatest factor in Poiseuille’s law affecting flow is
radius/diameter
if diameter in stenosis is 1/2 the original lumen, the flow will be reduced ___ times
16 times
r^2
increase in viscosity will ___ resistance
increase
increase in tube length will ___ resistance
increase
increase in diameter will ___ resistance
decrease
decrease in diameter will ___ resistance
increase
2 types of fluid energy
potential, kinetic
E total =
E potential + E kinetic
potential energy is
intravascular pressure and gravitational potential energy
kinetic energy is
related to motion of blood
Bernoulli principle
increase in velocity of fluid occurs simultaneously with a decrease in pressure or potential energy
pressure and velocity are ___ related
inversely
when blood accelerates/decelerates energy is
converted back and forth from potential to kinetic anc back
an increase in velocity will cause a ___ in P
decrease
parabolic flow profile
laminar flow, speed varies across tube, highest in center, slowest at edges,
average velocity in laminar flow
= 1/2 max speed
plug flow
laminar flow, flattened parabola, more uniform in speed
plug flow is usually found in
large vessels, at branch points
jet flow
high velocity at narrowing
disturbed flow
mild turbulence
disturbed flow occurs at
bifurcations, curves, near heart
turbulent flow
non-linear, multiple directions and velocities,
turbulent flow is found at
distal to stenosis
Reynolds number
predicts turbulence
Reynolds number =
> 2000 = turbulence
Reynolds number =
[average flow speed x tube diam x density ] / viscosity
2 patterns of pulsatile flow
high res, low res
organs supplied by low res
essential for life, need constant perfusion
RI =
A-B / A
PI =
A- B / mean
S/D
PSV /EDV
BOUNDARY layer
layer of fluid in which the surface of the vessel wall has exerted its influence by means of viscous drag
velocity at boundary layer
0 at wall
boundary layer separation
free boundary between layers of fluid moving in opposite directions, can be found in carotid bulb
flow preceding stenosis
slows down
flow at stenosis
jet
flow after stenosis
turbulence
flow further after stenosis
tardus parvus
Reynolds
effects of change of diameter and speed on fluid flow patterns
most common variant of aortic arch
bovine arch = common origin of brachiocephalic/innominate and LCCA