Heme Synthesis

Question 1

——- inhibits amino levulinic acid synthase

Answer 1

Heme and hematin

Question 2

What is the oxidized form of heme

Answer 2

Hematin

Question 3

What regulates heme synthesis in the bone marrow

Answer 3

Ferrous iron availability

Question 4

Heme is a complex of ferrous iron and ——-

Answer 4

Protoporhyrin 4

Question 5

Porphyrin is a cyclic compound formed by the linkage of ————- through——-

Answer 5

4 pyrole molecule
Methenyl bridges

Question 6

A Globular protein made up of single polypeptide chain of 153 a.a. residues is ——

Answer 6

Myoglobin

Question 7

The His residue coordinated to the heme in myoglobin is ————

Answer 7

His93 (also called F8).

Question 8

Hemoglobins is Composed of ——polypeptide chains ———𝛼 chains and ——-/β chains, held together by non covalent interactions.

Answer 8

four polypeptide chains
two 𝛼 chains and
two β chains

Question 9

Heme
-Synthesis is most active in ——and liver for incorporation into Hemoglobin and Cytochromes

Answer 9

born marrow

Question 10

——-is Composed of four polypeptide chains- two 𝛼 chains and two β chains, held together by non covalent interactions.

Answer 10

Hemoglobins

Question 11

Myoglobin can bind only to ——-molecules of O2;

Answer 11

One