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Board Review - C - Heme/Oncology > Heme/Onco I > Flashcards

Heme/Onco I Flashcards

1
Q

anisocytosis

A

variable size

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2
Q

poikilcytosis

A

variable shape

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3
Q

RBC membrane

A

Cl/HCO3 antiport

export HCO3 and transport CO2 from periphery to lungs

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4
Q

GpIIb/IIIa

A

fibrinogen receptor

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5
Q

platelet granules

A

dense - ADP and Ca

a- vWF and fibrinogen

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6
Q

band cells

A

immature neutro

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7
Q

polysegmented neutro

A

B12/folate deficiency

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8
Q

chemotaxis of neutrophils

A 
C5a
IL-8
LTB4
kallikrein
PAF
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9
Q

lipid A

A

from LPS

bind CD14 on macros - septic shock

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10
Q

macrophage activation

A

IFN-gamma

can present MHC II - antigen presentation

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11
Q

major basic protein

A

from eosinophil

defense against helminth

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12
Q

basophil content

A

heparin

histamine

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13
Q

mast cell

A

bind Fc of IgE

release histamine, heparin, eosinophil chemotactic factors

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14
Q

dendritic cell

A

APC

MHC class II

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15
Q

lymphocyte

A

B cell
T cells
NK cells

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16
Q

CD28

A

for T cell activation

17
Q

cross placenta

A

IgG

18
Q

universal blood donor

A

O group

19
Q

universal blood recipient

A

AB group

20
Q

Rh incompatible

A

Rh - mother - make anti-D IgG - cross placenta

hemolytic disease of newborn (erythroblastosis fetalis)

tx - rhogam

Rh = D

21
Q

plasma Abs for A and B blood groups

A

IgM

22
Q

extrinsic coag

A

tissue factor to factor VII

23
Q

intrinsic pathway

A

collagen to factor XII

also - activated by HMWK - kinin cascade

24
Q

epoxide reductase

A

reduces vitamin K - to active clot factors

25
Q

factor V leidein mutation

A

factor V resistant to inhibition by protein C

26
Q

source of vWF

A

endothelial cell - wiebel paladie body

platelet - a-granules

27
Q

platelet binding

A

release Ca and ADP, and TXA2

ADP - induces GpIIb/IIIa on platelet surface

28
Q

aspirin

A

inhiit COX

inhibit TXA2

29
Q

ristocetin

A

vWF binding Gp1b

diagnosis of vWD and BS syndrome

30
Q

inhibit GpIIb/IIIa

A

abciximab
eptifibatide
tirofiban

31
Q

acanthocyte

A

spur cell

32
Q

ringed sideroblast

A

sideroblast anemia

excess iron in mito

33
Q

schistocyte

A

helmet cell

with hemolysis mechanical

CID, TTP/HUS, HHELLP, heart valve

34
Q

sickling

A

with dehydration, deoxygenation, and high altitude

35
Q

dacrocyte

A

teardrop shaped

bone marrow infiltration

36
Q

target disease

A

HbC disease
asplenia
liver
thalassemia

37
Q

heniz body

A

oxidation of Hb SH group to disulfide bond

precipitate

phagocytosed - bite cells

with G6PD deficiency

38
Q

howel jolly bodies

A

nuclear remnants in RBCs

normal removed by splenic

indicate hyposplenia or asplenia

Board Review - C - Heme/Oncology (4 decks)

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