Heme/Onco I

Question 1

anisocytosis

Answer 1

variable size

Question 2

poikilcytosis

Answer 2

variable shape

Question 3

RBC membrane

Answer 3

Cl/HCO3 antiport

export HCO3 and transport CO2 from periphery to lungs

Question 4

GpIIb/IIIa

Answer 4

fibrinogen receptor

Question 5

platelet granules

Answer 5

dense - ADP and Ca

a- vWF and fibrinogen

Question 6

band cells

Answer 6

immature neutro

Question 7

polysegmented neutro

Answer 7

B12/folate deficiency

Question 8

chemotaxis of neutrophils

Answer 8

C5a
IL-8
LTB4
kallikrein
PAF

Question 9

lipid A

Answer 9

from LPS

bind CD14 on macros - septic shock

Question 10

macrophage activation

Answer 10

IFN-gamma

can present MHC II - antigen presentation

Question 11

major basic protein

Answer 11

from eosinophil

defense against helminth

Question 12

basophil content

Answer 12

heparin

histamine

Question 13

mast cell

Answer 13

bind Fc of IgE

release histamine, heparin, eosinophil chemotactic factors

Question 14

dendritic cell

Answer 14

APC

MHC class II

Question 15

lymphocyte

Answer 15

B cell
T cells
NK cells

Question 16

CD28

Answer 16

for T cell activation

Question 17

cross placenta

Answer 17

IgG

Question 18

universal blood donor

Answer 18

O group

Question 19

universal blood recipient

Answer 19

AB group

Question 20

Rh incompatible

Answer 20

Rh - mother - make anti-D IgG - cross placenta

hemolytic disease of newborn (erythroblastosis fetalis)

tx - rhogam

Rh = D

Question 21

plasma Abs for A and B blood groups

Answer 21

IgM

Question 22

extrinsic coag

Answer 22

tissue factor to factor VII

Question 23

intrinsic pathway

Answer 23

collagen to factor XII

also - activated by HMWK - kinin cascade

Question 24

epoxide reductase

Answer 24

reduces vitamin K - to active clot factors

Question 25

factor V leidein mutation

Answer 25

factor V resistant to inhibition by protein C

Question 26

source of vWF

Answer 26

endothelial cell - wiebel paladie body

platelet - a-granules

Question 27

platelet binding

Answer 27

release Ca and ADP, and TXA2

ADP - induces GpIIb/IIIa on platelet surface

Question 28

aspirin

Answer 28

inhiit COX

inhibit TXA2

Question 29

ristocetin

Answer 29

vWF binding Gp1b

diagnosis of vWD and BS syndrome

Question 30

inhibit GpIIb/IIIa

Answer 30

abciximab
eptifibatide
tirofiban

Question 31

acanthocyte

Answer 31

spur cell

Question 32

ringed sideroblast

Answer 32

sideroblast anemia

excess iron in mito

Question 33

schistocyte

Answer 33

helmet cell

with hemolysis mechanical

CID, TTP/HUS, HHELLP, heart valve

Question 34

sickling

Answer 34

with dehydration, deoxygenation, and high altitude

Question 35

dacrocyte

Answer 35

teardrop shaped

bone marrow infiltration

Question 36

target disease

Answer 36

HbC disease
asplenia
liver
thalassemia

Question 37

heniz body

Answer 37

oxidation of Hb SH group to disulfide bond

precipitate

phagocytosed - bite cells

with G6PD deficiency

Question 38

howel jolly bodies

Answer 38

nuclear remnants in RBCs

normal removed by splenic

indicate hyposplenia or asplenia