Heme/Onc - Week 3 Review - Part 1

Question 1

Aniscytosis - Definition

Answer 1

RBC with range of sizes (High RDW)

Question 2

Poikilocytosis - Definition

Answer 2

RBCs with different shapes (e.g. spherocytes or sickle cells)

Question 3

Red Cell Chromasia (MCHC) - Definition

Answer 3

How red is a cell (based on Hb)

Question 4

What is this shown in the picture? + Key Points (3)

Answer 4

Anisopiokilocytosis

Iron Deficiency Anemia with INcreased RDW

Question 5

What is shown in the picture? What disease is shown? What other diseases have these cells?

Answer 5

Thalassemia - Target Cells

Also HALT - Hemoglobin C + Asplenia + Liver Disease + Thalasemia + Low Fe (Lecture)

Question 6

What is shown on this image (2) + Common Disease Causing (2)

Answer 6

Hyper-segmented Neutrophils + Macrocytic RBCs

B12 + Folate Deficiency

Question 7

What findings are shown on the image? (2) + What diseases cause the findings? (1)

Answer 7

Bite Cells + Heinz Bodies

G6PD

Question 8

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 8

Sickle Cells

Sickle Cell Anemia

Question 9

What findings are shown on the image? (1) + What diseases cause the findings? (4)

Answer 9

Schistocytes - Microthrombi Damage

TTP + HUS + DIC + Mechanical Heart Valves

Question 10

What findings are shown on the image? (2) + What diseases cause the findings? (2)

Answer 10

Spherocytes - HIgh MCHC

Herditary Spherocytosis (Spectrin/Ankyin/Band 3,1)

Warm Autoimmune Hemolytic Anemia (Extravascular Hemolysis - IgG)

Question 11

What findings are shown on the image? (2) + What diseases cause the findings? (2)

Answer 11

Acanthocytes (Spur Cells)

Liver Disease + Abetapoproteinuria

Question 12

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 12

Rouleux Formation

Multiple Myeloma

Question 13

What findings are shown on the image? (1) + What diseases cause the findings? (2)

Answer 13

Cold Agglutinin

IgM Mediatated Immune Hemolytic Anemia (Compliment) + Mycoplasma Pneuomina

Question 14

What findings are shown on the image? (1)

Answer 14

Reticulocyte

Question 15

What findings are shown on the image? (2) + What diseases cause the findings? (1)

Answer 15

Howell Jolly Bodies - Don’t need special stain vs. Heinz Does

Asplenia

Question 16

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 16

Basophilic Strippling

Lead Posioning

Question 17

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 17

Maltese Cross

Babasia

Question 18

What findings are shown on the image? (2) + What diseases cause the findings? (1)

Answer 18

Hemoglobin C Crystal + Target Cells

Hb C - Extravascular

Question 19

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 19

Iron build up around the nucleus in mitochondria due to lack of porporphoryin synthesis

Sideroblastic Anemia

Question 20

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 20

Smudge Cell

CLL- CD5 and CD23 +

Question 21

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 21

Popcorn Cells

Lymphocyte Predominant Hodgkin Lymphoma - Not CD15/30+

Question 22

What findings are shown on the image? (1) + What diseases cause the findings? (1)

Answer 22

Hairy Cell Leukemia

CD103 + TRAP+

Question 23

What findings are shown on the image? (2) + What diseases cause the findings? (1)

Answer 23

TRAP+ and Fried Egg Appearance

Hairy Cell Leukemia

Question 24

What findings are shown on the image? (2) + What diseases cause the findings? (1)

Answer 24

Starry Sky + Tingible Body Macrophages

Burkitt’s Intermediate B-Cell Lymphoma - c-myc translation (8-14) - EBV Assocation