Heme/Onc Questions + Formatives Review Flashcards
Immune Deficiency Linked to Increased Lymphomas
Wiskott Aldrich (T-Cell) - X-Linked
Teenage Mass with CD2 and CD7
Lymphoblastic Lymphoma - T-Cell + Teenager + Thymus
Follicular Lymphoma - Sample Markers (2) + Translocation
CD5 -
CD10 +
t:18:14 - Bcl2
CLL - Markers (3) + Smear vs. ALL
Markers - CD5+ / CD19+ / CD20+
Smear = Smaller more mature cells - Also usually smudge cells
Russell Bodies - 2 Disease + Key Difference
Russell Bodies - Multiple Myeloma + Waldenstrom-Macroglobulinemia (Lymphoblastic Lymphoma)
Anaplastic Large Cell Lymphoma (4)
ALK
2,5 Trans-location
Horseshoe Shaped Cells
CD-30
Drugs interacting with Methotraxate (4)
1) Aspirin
2) NSAIDS
3) Penicillins
4) Cephalosporins
HER2 Breast Cancer Drugs (3)
1) Tratsuzumab
2) Lapatinib
3) Peruzumab
Drug Correlated with Rash Efficacy (1) - 3 Keys
Erlotinib - EGFR Tyrosine Kinase Inhibitor
Used for Non-Small Cell Lung Cancer
CYP3A4
HPV - Carcinogenesis Pathway
Blocks Rb protein - No Rb protein = no inhibition of Cyclin D1 - Easy progression from G1-S
Von Hipple Lindaue - Genetics + Mechanism
1) Autosomal Dominant
2) Loss of VHL allows stabilization of HIF = Allows tumor angiogenesis
ATRA Syndrome - Cause + Findings (4)
ARTA - Used for 15/17 translocation in AML-M3
Cytokine storm - Causes hypotension + pleural effusions + respiratory distress + can be deadly
5-FU - Key Deficiency
Dihydropyrimidine dehydrogenase
Pneumocystis Carini - Key Immune Deficiency
Hyper IgM - Defective CD40 - X-Linked Recessive
AML - Poor Prognosis Markers (4)
1) 9:22 + 9:11 + Loss of Chromosomes
LAD-1 - Inheritance + Missing Marker + Triad
Autosomal Recessive
Missing CD18
Delayed Separation of the Umbilical Cord
Job’s Syndrome - 4 Keys
1) Hyper IgE Syndrome (B-Cell) - Eosinophilia
2) Triad - Eosinophilia + Eczema + Recurrent Sinopulmonary Infactions
3) Autosomal Dominant
4) JAK/STAT3 Over-activation
Myeloperoxidase Deficiency - 3 Keys
Loss of Conversion of H2O2 to HOCl
Increased Candida Infection
Normal Nitro Blue Test
LAP Stain - Uses (2)
LAP+ = Leukemoid Reaction (Acute Infection LAP- = CML
CML = Basophils vs. Acute Leukemoid = Neturophils
CML - Lots of granulocytes (lots of lobs)
CML Keys
1) Classicly presents just with elevated WBC/Hb/Platelet and Enlarged Spleen
2) t(9:22) BCR-Abl - RIsk of AML/ALL Progression
3) Treatment = Busulfan
Heriditary Spherocytosis - Key Points (3)
1) Red Spherocytes - Normocytic + Extravascular
2) Autosomal Dominant
3) Spectin/Anykin
4) Osmotic Fragility Test
Major Tests for Heme/Onc (8)
1) Nitro Blue - Chronic Granulomatous Disease
2) D-Dimer - DIC
3) Schilling Test - B12
4) Metabisulfite Test - HbS - Trait/Disease
5) Osmotic Fragility - Heriditary Spherocytosis
6) Sucrose Test - PNH + CD55 Follow-Up
7) Ristocetin Test - Benard Soulier + vWF Disease
8) Mixing Test - Lack of a Factor vs. Ab against a Factor
3 Transfusion Issues Prevented by Leukodelpletion
1) TRALI
2) Febrile Reaction
3) CMV infection
TRALI - Keys (4)
1) 1-2 Hours After Transfusion
2) Severe Hypotension + Pulmonary Edema
3) Antibodies against donor HLA - Antibodies cause massive immune reaction with endothelial damage and fluid leak (pulm. edema)
4) #1 Cause of Transfusion Death
Mantle Cell Lymphoma - CD Marker + Translocation
CD5 Positive
t:11/14 - Cyclin D1
Horseshoe Shaped Nuclei
ALK - T-Cell + CD30 + 2,5 Trans
Cloverleaf Cells - Disease + Findings (2)
A-TALL - Aggressive + HLTV-1 Infection
Diseases with Large Platelets
1) ET
2) ITP
3) Bernard Soiler
High Uric Acid - Class of Diseases
Myeloproliferative
Darocytes
Tear Drop Cell - Myelofibrosis - Fibrosis of bone marrow with intravascualr hemolysis and atypical megakarocytes - extramedullay hematopoesis
