Heme/Onc - short n sweet Flashcards
testicular cancer metastasizes where?
lung
lung cancer metastasizes where?
brain
prostate/breast cancer metastasize where?
bone
colon cancer metastasizes where?
liver
cervical cancer metastasizes where?
peritoneum
side effects of monoclonal antibodies
heart failure, stroke, bowel perforation
side effects of enzyme inhibitors
neutropenia, thrombocytopenia
side effects of antimicrotubulars
vincristine: phlebitis, cellulitis
paclitaxel: neutropenia, peripheral neuropathy, bradycardia
side effects of GnRH analogs
impotence, hot flashes
side effects of aromatase inhibitors
osteoporosis
side effects of SERMs
NVD, stomatitis, alopecia, ulcers
side effects of alkylating agents
secondary malignancies
tumor marker alpha-fetoprotein used for
hepatocellular carcinoma
tumor marker Bence Jones proteins used for
multiple myeloma
tumor marker beta-HCG used for
germ cell tumors, hydatidiform moles, choriocarcinoma of uterus
tumor marker BRCA1/2 used for
risk of breast/ovarian/prostate cancer
tumor marker CA 19-9 used for
pancreatic, hepatobiliary cancer
tumor marker CA-125 used for
ovarian cancer
tumor marker CEA used for
MAIN ONE: colorectal, but also breast, pancreatic, gastric, hepatobiliary, small cell lung cancer
tumor marker PSA used for
prostate cancer
renal cell cancer & melanoma metastasize where?
brain
unique side effect of antimetabolites
ulcerative stomatitis
most common inherited hypercoagulable state
activated protein c resistance
most common heritable cause of venous thrombosis
factor V leiden
most common acquired hypercoagulable state
malignancy
1 in 5 patients with recurrent pregnancy loss have
lupus anticoagulant antibodies
1 in 5 patients <45 with a stroke have
lupus anticoagulant antibodies
Lambert-Eaton myasthenia
small cell lung cancer
lymphatic spread/metastasis
carcinomas
hematogenous spread/metastasis
sarcomas
seeding of body cavities
ovarian cancer
phlebotomy treats
hemochromatosis, polycythemia vera
90% of those who get carcinoid syndrome have
hepatic metastases
