Heme Onc 2 Flashcards
What do CD15 and CD30 represent?
Reed Sternberg cells and Hodgkins lymphoma.
What is the translocation of the cancer that affects kids, gives a “starry sky appearance, is associated with jaw lesions in Africa (pelvis/abdomen in US) and EBV?
Burkitt lymphoma.
t(8;14)- c-myc
[and less common: t(8,22) and t(2,8)]
What is the translocation of the cancer that usually affects older adults, but 20% in kids, and is the most common type of non-Hodgkin lymphoma?
Diffuse large B-cell. t(14;18)
What cancer is CD5+ and has a translocation of cyclin D1 and heavy-chain Ig?
Mantle Cell.
t(11;14)
What cancer is a translocation of heavy chain Ig and bcl-2?
Follicular lymphoma.
t(14;18)
What does the mnemonic CRAB stand for?
Multiple Myeloma.
hyperCalcemia
Renal insufficiency
Anemia
Bone lytic lesions/Back pain
What two disease have M-spikes? How can you differentiate?
MM: M-spike = IgG, primary amyloidosis, punched out lytic bone lesions, Rouleaux formations
Waldenstrom: M-spike = IgM, hyperviscosity, no lytic bones lesions.
t(12,21)
CD10+, TdT+, CALLA+
Can present with increased lymphoblasts and mediastinal mass.
ALL
CD5+, CD20+ B-cell neoplasm
Smudge cells
Pts > 60yo
Small lymphocytic lymphoma, or
Chronic lymphocytic lymphoma
Cells have hair-like projections
Stains tartrate-resistant acid phosphatase (TRAP) +
Marrow fibrosis => dry tap
Hair cell leukemia
Tx: pentostatin and cladribine (2-CDA) an adenosine analog that inhibits adenosine deaminase
Auer rods
Peroxidase+
Big increase in circulating myeloblasts on peripheral smear
Prior exposure to chemotherapy/radiation is a risk factor
Acute myelogenous leukemia
Tx: ATRA
t(9,22), BCR-ABL
Low leukocyte alkaline phosphatase
Peak incidence 45-85yo
CML
Tx: Imatinib (prophylax with allopurinol for tumor lysis syndrome)
Note: may accelerate and transform to AML or ALL
