Heme- FC

Question 1

How to treat anemia in lupus?

Answer 1

etanercept: treating UNDERLYING CONDITION in anemia with chronic disease
* I picked EPO. Although it helps anemia, treating underlying condition is the first line. If treating underlying condition is not an option, then the next one is EPO

Question 2

What is HbH?

Answer 2

Beta4
: occurs in alpha thalassemia intermedia- 3 alpha deletion

*Hb Barts is gamma4, occurs in deletion of all 4 alpha

Question 3

tPA administration results in massive hemorrhage. What needs to be added?

Answer 3

cryoprecipitate, which contains fibrinogen

Question 4

multiple myeloma

• serum albumin level
• RBC level
• platelt level

Answer 4

ALL decreased

monocloncal plasma cells can infiltrate bone marrow, resulting in low RBC and platelet

Albumin is also low as inflammatory mediators can impair liver’s normal function in albumin synthesis