Heme

Question 1

HEMATOLOGY

Answer 1

HEMATOLOGY

Question 2

What is the normal range for MCV?

Answer 2

80-100

Question 3

What is the most common microcytic anemia?

Answer 3

Iron deficiency anemia

Question 4

Would anemia of chronic disease most likely be macrocytic normocytic or microcytic?

Answer 4

Normocytic

Question 5

What two main causes should you be thinking of in a macrocytic anemia?

Answer 5

Malnutrition (B-vit) and severe blood loss

Question 6

Does an increase in reticulocytes indicate a decrease or an increase in RBC production?

Answer 6

An increase, reticulocytes are newly released “baby” RBC’s

Question 7

Auer rods are most commonly associated with what disease?

Answer 7

Acute myeloid leukemia

Question 8

What molecule binds iron in the blood stream?

Answer 8

Transferrin

Question 9

What does koilonychia refer to?

Answer 9

Spoon-shaped nails which may be found in microcytic anemia.

Question 10

Will the serum ferritin be high or low in a patient with iron deficient anemia?

Answer 10

It will almost always be low.

Question 11

A low retic count and a normal serum ferritin should make you think of what diagnosis?

Answer 11

Anemia of chronic disease

Question 12

Under normal conditions at what hemoglobin level would you begin to consider a transfusion?

Answer 12

8

Question 13

Asplenism secondary to sickle cell disease increases a patient’s risk for what type of infections?

Answer 13

Capsulated organisms like Strep pneumo and H. flu

Question 14

An African American teenager presents with avascular necrosis of the his right femoral head. What is the most likely diagnosis?

Answer 14

Sickle cell disease

Question 15

How do you treat a sickle cell crisis?

Answer 15

Fluids, oxygen pain medication transfusion may be necessary

Question 16

Will unconjugated bilirubin be high or low in a patient with sickle cell disease?

Answer 16

High

Question 17

Which anemia should you think of if you see the term Howell-Jolly bodies?

Answer 17

Sickle cell due to the functional asplenia but it may also show up in folic acid deficiency.

Question 18

G6PD deficiency follows what pattern of inheritance?

Answer 18

X- linked

Question 19

List the three diagnosis you should be thinking of if a question includes Heinz bodies.

Answer 19

G6PD deficiency anemia, chronic liver disease alpha thalassemia

Question 20

What is pica?

Answer 20

Eating non-food items including ice, paper, dirt hair.

Question 21

Are target cells seen in mild or severe iron deficiency anemia?

Answer 21

Severe, they are also seen in alpha thalassemia chronic liver disease and asplenia.

Question 22

Iron deficiency anemia will have a serum iron lower than what value?

Answer 22

30

Question 23

Would a B12 deficiency anemia most likely be microcytic, normocytic or macrocytic?

Answer 23

Macrocytic

Question 24

You should be thinking alpha thalassemia if the question stem includes which four geographic areas?

Answer 24

Southeast Asia, China, Middle East, Africa

Question 25

A patient of Mediterranean descent is a clue for which type of anemia?

Answer 25

Beta thalassemia

Question 26

In a folic acid deficiency anemia the folic acid level is typically below what level?

Answer 26

<150

Question 27

What hematological disorder should you think of if the questions talks about the patient eating ice or dirt?

Answer 27

Iron deficiency anemia

Question 28

Inability to absorb vitamin B12 due to lack of intrinsic factor is what disease?

Answer 28

Pernicious anemia

Question 29

Stocking glove paresthesias should make you think of what two diagnoses?

Answer 29

B12 deficiency neuropathy and diabetic neuropathy

Question 30

Will the RBC’s be large, small, or normal size in a B12 deficient anemia?

Answer 30

Macrocytes

Question 31

Will the retic count be elevated decreased or normal in a B12 deficient anemia?

Answer 31

Retic count will be low. Low building blocks means low production.

Question 32

What is Schilling’s test used for?

Answer 32

Test for the cause of a B12 deficiency.

Question 33

Strict vegans are at risk for what type of anemia?

Answer 33

B12 deficiency anemia

Question 34

Is sickle cell microcytic macrocytic or normocytic?

Answer 34

Microcytic

Question 35

Will a hemolytic anemia generally have an elevated or decreased retic count?

Answer 35

Elevated

Question 36

List four disease states in which you may find basophilic stippling.

Answer 36

Lead poisoning, beta or alpha thalassemia, sideroblastic anemia, arsenic poisoning

Question 37

If a question presents a pregnant woman with anemia what is the most likely diagnosis?

Answer 37

Iron deficiency

Question 38

The term Philadelphia chromosome should make you think of what diagnosis?

Answer 38

Chronic myeloid leukemia