Heme Flashcards
Treat major bleeding with warfarin
IV vit K
4f-PCC
Fluids
HL anemia
Hypocellular bone marrow
Unprovoked thrombosis
Lack of CD55 and CD59
Dx?
PNH
New Budd-Chiarri.
Lab workup(1)
JAK2
Hemophilia results
PT
PTT
Mixing study
Normal
Elevated
Corrects PTT
Phil chromosome
Disease?
Treatment?
9:22
CML, but can be seen in others
Imatinib or dasatinib
Suspected PE in pregnant patient
First test?
DVT US
If negative, then VQ scan
CTPE if no VQ available
Hemolytic anemia
Microcytosis
Target cells
Small amt of A2 and F Hb
Dx?
Beta-thal
Alpha-thal will not have A2 or F
Treatment of acquired hemophilia.
1 with low factor 8 inhibitor levels
2 with high factor 8 inhibitor levels
Recomb factor 8
Recombinant factor 7
When to treat essential thrombasthenia
Age > 60
Plt > 1 million
Prior venous or arterial thrombosis (or risk factors for thrombosis such as DM or HTN)
Hemochromatosis diet
Avoid raw seafood
Bleeding out of proportion to thrombocytopenia
Auer rods
15:17 translocation
Dx?
Tx?
APL
ATRA
Coumadin Pt with INR < 9 and no bleeding
No routine use of vit K
Just hold Coumadin
Coag results in liver disease
PT
PTT
Factors V Vii Viii
High PT and PTT and high factor viii
Low factor 5 and 7
Genetic mutation in CML
BCR-ABL transporter
Clonal lymphocytic cells
Plasmatoid lymphocytes
Blasts > 10% of bone marrow
Night sweats, weight loss
Anemia, LAD
Dx? Tx?
Waldenstrom macroglobulinemia
Rituxan and chemotherapy
