HEME

Question 0

Hodgkin vs Non-Hodgkin Lymphoma

Differences (3 Gen Path, Char Cells, 2 Epi, Assoc, Pres, Prog)?

Answer 0

• Groups of Nodes: Localized single vs Multiple peripheral
• Extranodal Involvement: Rare vs Common
• Spread: Contiguous vs Noncontiguous
• Reed-Sternberg cells vs B cells (majority) / T cells
• Gender: MC in men (except for nodular sclerosing type)
• Age: Young adulthood + > 55 yrs (Bimodal distribution) vs 20-40
• Assoc: EBV (50% of cases) + Minimal Change Dz vs
  HIV / Immunosuppression + Hashimoto’s
• Pres: “B” s + s vs Fewer constitutional s + s
• Prognosis: Better (stage = strongest predictor) vs Worse

Question 1

Leukemoid Reaction vs CML- similarities (3) & difference?

Answer 1

Similarities = all cellular findings (3):

• WBC count↑
• Neutrophils↑
• Neutrophil precursors (eg band cells)↑= “Left Shift”

Difference =↑Leukocyte ALP in Leukemoid Reaction vs↓in CML.

Question 2

PV vs Reactive Polycythemia (2)

Answer 2

• Erythropoietin (EPO):↓vs↑

- O2 Sat: Normal vs Low (unless ectopic EPO production from RCC = normal)

Question 3

Multiple Myeloma vs Waldenstrom’s Macroglobulinemia (2)

Answer 3

• ‘M Spike’ on SPEP: Due to IgG / IgA vs IgM

- Lytic Bone Lesions: YES vs NO