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BCOP > HEME > Flashcards

HEME Flashcards

1
Q

How did we reduce bortezomib-associated PN?

A

Subcutaneous!! (Weekly dosing has same amount as biweekly, but patients could tolerate higher doses)

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2
Q

What combinations of daratumimab can be used first-line in transplant eligible patients?

A

Dara-VRd

Dara-VTd

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3
Q

What’s the mechanism of daratumimab?

A

Anti-CD 38

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4
Q

What’s the difference between KRd and VRd

A

KRd had higher composite of cardiac/renal/pulmonary side effects. VRd had more PN

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5
Q

Why do we use low-dose dexamethasone?

A

Low-dose dex (weekly) had improved OS from less infectious complications and lower rate of VTE than high-dose dex (pulse dosing)

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6
Q

What line of treatment is selinexor approved in?

A

5th+

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7
Q

How many drugs should be used for transplant eligible initial treatment? What about non-transplant?

A

3-4

2-4

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8
Q

What anticoagulant prophylaxis is used for patients on IMIDs at high risk for VTE per the IMPEDE?

A

Warfarin (goal 2-3)
Dateparin 5000IU
Enoxaparin 40U daily
Apixaban 2.5 mg BID

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9
Q

What are the BBWs for pabinostat?

A

Cardiac arrhythmia, ischemia

Diarrhea

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10
Q

What combination is pabinostat approved with?

A

Vd

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11
Q

What treatment line is pomalidomide approved in?

A

NOT first

Used with dexamethasone

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12
Q

What is the MOA of isatuximab?

A

Anti-CD38

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13
Q

What is supportive care required for daratumimab?

A

Antiviral for at least 3 months after treatment
Premedications with corticosteroid, APAP, and antihistamine
Type and screening prior to initiation

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14
Q

What’s in PACE?

A

Cisplatin
Doxorubicin
Cyclophosphamide
Eroposide

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15
Q

What supportive care is needed with PACE?

A

Antifunfal and antibacterial ppx during periods of neutropenia
GF support
Antiviral if getting bortezomib with it (VT-PACE)

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16
Q

What is the weekly dose of bortezomib? And what is biweekly dose?

A 
Weekly = 1.5 mg/m2
Biweekly = 1.3 mg/m2
17
Q

What are high risk genetic mutations for MM?

A

Del 17p
T(14;16)
T(4:14)

18
Q

What are requirements for “active” MM?

A

BMPC at least 10%
+ something clinical (CRAB)
OR BMPC at least 60%, FLCR >100 or <0.01, or focal marrow lesion at least 5 mm

19
Q

T/F: Transplant should be the goal following induction for patients with MM

A

False - equal outcomes with transplant vs maintenance, so patient specific…

20
Q

Maintenance therapy approved for MM?

A

Lenalidomide
Bortezomib
Ixazomib (only transplant eligible)
Lenalidomide+bortezomib

21
Q

What is the microglobulin protein level considered high risk?

A

> 5.5! (<3.5 is low risk)

22
Q

For non-transplant MM patients, what regimens are approved with daratumimab?

A

Dara-Rd
Dara- velcade- melphalan - prednisone
Dara-CyBorD

23
Q

What’s the MOA of belantomab mafodotin ?

A

ADC targeting BMCA w/MMFA (microtubule inhibitor)

24
Q

What are ADEs of blenrep?

A

Ocular toxicity! REMS program requires eye appts before each dose and ocular lubricants QID throughout treatment

25
Q

For MM, which bone modifying agent is preferred??

A

No preference - pamidronate, Zometa, or Xgeva

26
Q

What is the dose of Xgeva for bone metastases?

A

120mg SC monthly

27
Q

When is furosemide used in management of MHC?

A

Only AFTER fluid has been restored. Used to continue hydration without overload

28
Q

Which of the IMIDs has the highest risk of secondary malignancies?

A

Lenalidomide

29
Q

Which of the IMIDs has the highest risk of PN?

A

Thalidomide

30
Q

Which of the IMIDs cause the most myelosuppression?

A

Lenalidomide and pomalidomide

31
Q

Which of the IMIDs has the most renal toxicity?

A

Lenalidomide

32
Q

What is the recommendation for treatment of VTE in patient with platelet count 25-50K?

A

Enoxaparin half dose

33
Q

Which patient population should avoid DOACs?

A

Gastric or gastroesophageal lesions

34
Q

Fondaprinux is contraindicated when?

A

CrCl < 30

BCOP (2 decks)

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