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MCM > hematopoisis > Flashcards

hematopoisis Flashcards

1
Q

When is red blood cells formed in the yolk sac?

A

3-8 weeks

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2
Q

When is red blood cells formed in the liver?

A

fetus: 6-30 weeks

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3
Q

When is red blood cells formed in the spleen?

A

fetus: 28 weeks

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4
Q

When is red blood cells formed in the bone marrow?

A

28 weeks onward

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5
Q

Where does hematopoiesis occur in the adult

A

skull, clavicle, verebrae, ribs, pelvis, sternum, ends of long bones

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6
Q

What does the hematopoietic compartment consist of?

A

highly vascular, hematopoietic stem cells including committed precursor cells and maturing cells

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7
Q

What does the marrow stromal compartment consist of?

A

production of growth factors, barrier (endothelial cells), adipose cells, macrophages

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8
Q

what is BFU-E

A

colony forming unit for RBC

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9
Q

what is CFU-mega

A

megakaryocyte precursor

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10
Q

what is CFU-GM

A

monocyte and neutrophil

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11
Q

what is prothymocyte?

A

T lymphocyte precursor

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12
Q

Characteristics of Stem cell factor

A

SCF-produced by fetal tissue and bone marrow;
weak stimulator of pluripotent cell;
makes stem cells responsive to other cytokines

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13
Q

Flt3

A

related to SCF; acts like SCF

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14
Q

What does IL-3 do?

A

myloid cell line differentiation

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15
Q

What does IL 1 do?

A

Develop lymphoid cells (B,T)

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16
Q

What does IL-4 do?

A

Develop lymphoid cells (B,T)

17
Q

What does IL-2 do?

A

In absence of other IL then it develops T cells from lymphocytes;
if IL-6 is present then it makes B cells

18
Q

What does IL-6 do?

A

It makes B cells from lymphocytes

19
Q

What does GM-SF do?

A

forms leukocytes and reticulocytes

20
Q

what does G-CSF do?

A

increase neutrophils

21
Q

M-CSF

A

stimulates monocytes and macrophages

22
Q

keynote characteristics of erythropoiesis

A

large central nucleus in pro stage;

enters blood as reticulocyte (nucleus gone, but residual polyribosomes on stain)

23
Q

Keynote characteristics of thrombocyte development

A

kidney shape nucleus in megakaryoblast;
huge megakaryocyte;
spits out platelets (very small)

24
Q

identify cells under a scope

A

ok

25
Q

What do neutrophils do?

A

phagocytize bacteria;

release antimicrobial chemicals

26
Q

What do eosinophils do?

A

phagocytize antigen-antibody complexes, allergens, inflammatory chemicals;
antiparasitic and antibacterial

27
Q

what do basophils do?

A

secrete histamine and heparin;

inflammatory rxns during immune responses and allergies

28
Q

keynote features of granulocyte synthesis

A

just before released into blood it has an indented nucleus;
horseshoe shaped nucleus in blood;
quartinary nucleus structure when mature

29
Q

what do monocytes do?

A

phagocytize pathogens and debri;
“present” antigens to other immune cells;
differentiate into macrophages

MCM (10 decks)

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