HEMATOPOIETIC DEVELOPMENT

Question 1

Begins around the 19th day of embryonic development after fertilization

Answer 1

Mesoblastic or yolk sac phase

Question 2

Cells from mesoderm migrate to yolk sac

Answer 2

Mesoblastic or yolk sac phase

Question 3

Formation of primitive erythroblast

Answer 3

Mesoblastic or yolk sac phase

Question 4

Primitive erythroblasts are important in early embryogenesis for the production of…

Answer 4

Hemoglobin (Gower-I, Gower-II, and Portland)

Question 5

Globin chain of Gower-I

Answer 5

2 zeta and 2 epsilon chains

Question 6

Globin chains of Gower-II

Answer 6

2 alpha and 2 epsilon

Question 7

Globin chains of Portland hgb

Answer 7

2 zeta and 2 gamma

Question 8

Begins at 5th to 7th week of gestation

Answer 8

Hepatic phase

Question 9

Liver becomes the major site of hematopoiesis

Answer 9

Hepatic phase

Question 10

Beginning of the production of megakaryocytes

Answer 10

Hepatic phase

Question 11

Predominant hgb in Hepatic phase

Answer 11

Hb F

Hb A are also detectable

Question 12

Stage for the beginning of definitive hematopiesis with a decline in primitive hematopoiesis

Answer 12

Hepatic phase

Question 13

Globin chains of Hb F

Answer 13

2 alpha and 2 gamma

Question 14

4th month of gestation, prior to the 5th month

Answer 14

Medullary (myeloid) development

Question 15

The primary site of hematopoiesis by the end of 24 weeks gestation

Answer 15

Bone marrow

Question 16

Main site of hematopiesis during the second and third trimester

Answer 16

Medullary (myeloid) phase

Question 17

Globin chains of Hb A

Answer 17

2 alpha and 2 beta

Question 18

Globin chains of Hb A2

Answer 18

2 alpha and 2 delta