Hematopoiesis I

Question 1

Bone Marrow Produces

Answer 1

Red Blood Cells White Blood Cells Platelets

Question 2

Hematopoietic Stem Cell HSC

Answer 2

can differentiate and form blood and immune cells HSC can renew itself HSC can mobilize out of the bone marrow into circulating blood HSC can restore long term hematopoietic function

Question 3

HSC blood cells

Answer 3

Red Blood Cells WBC Neutrophils, Lymphocytes, Monocytes, Eosinophils, basophils Platelets

Question 4

HSC Immune Cells

Answer 4

Mast Cells, Dendritic Cells, Osteoclasts

Question 5

Total Nucleated cells that are HSC?

Answer 5

<0.01%

Question 6

Markers on HSC

Answer 6

CD34, c-kit, c-MPL, MDR-1, THY 1+

Question 7

Sources of HSC

Answer 7

Bone Marrow Peripheral Blood Umbilical Cord

Question 8

History of Hematopoiesis

Answer 8

Begin in yolk sac in embryo/ fetus Transfer production to liver during 5th week of fetal development Bone marrow is main site of hematopoiesis from mid-fetal development to life.

Question 9

How many times can a HSC divide? How many progenitor cells does a HSC produce? What is HSC cell division an example of?

Answer 9

1 HSC can divide up to 18 times producing roughly 10,000 progenitor cells. HSC cell division is asymmetric cell division.

Question 10

Stromal Cells

Answer 10

Stromal Cells produce matrix Stromal cells regulate stem cells via proteins and glycoproteins that tell how HSC should divide Stromal Cells provide “soil” for HSC to grow

Question 11

Progenitor Cells of HSC

Answer 11

Common Myeloid Progenitor Common Lymphoid Progenitor

Question 12

Myeloid Lineage

Answer 12

Question 13

Are mature neutrophils more closely related to RBCs or Lymphocytes

Answer 13

RBCs via myeloid lineage

Question 14

Lymphoid Lineage

Answer 14

Question 15

Progenitor Cell

Answer 15

Lineage Commitment

Cannot Self Renew

Not differentiable under microscope

Question 16

What is the only cell of hematopoiesis that has a drug efflux pump?

Answer 16

Hematopoeitic Stem Cell