Hematopoiesis Flashcards
At what age does hematopoiesis in all marrow cavities end?
age of 4
In adults, hematopoiesis occurs in
axial skeleton and long bones (red marrow)
What are the growth factors that are non-lineage specific and act on both pleuripotent and multipotential stem cells?
IL-3, 7
GM-CSF (granulocyte-monocyte)
What are the lineage-specific growth factors?
G-CSF, M-CSF, IL-5, EPO, TPO
Cells that can give rise to all of the cell types that make up the body
Pluripotent Stem Cells
Cells that differentiate into either lymphoid or myeloid (non-lymphoid) cells
Multipotential (hematopoietic) Stem Cells
What is the order to hematopoietic stem cell development?
Hematopoietic –> Progenitor –> Precursor –> Differentiated Cells
Another term to describe reticulocyte?
Polychromatic erythrocyte
What is the last stage of erythropoiesis capable of division (mitosis)?
Polychromatophilic erythroblast
What is the last stage of granulopoiesis capable of division (mitosis)?
Myelocyte
What cells are predominant in adult bone marrow?
fat cells
There are more myeloid cells than _____ in adult bone marrow
erythroid cells
What is the life span of RBCs?
120 days
