hematopoiesis

Question 1

the first type of cell produced by the developing embryo

Answer 1

erythrocytes

Question 2

Percentage of fat tissue located in the bone marrow cavities of adults

Answer 2

50%

Question 3

Characteristics of pluripotent hematopoietic stem cells

Answer 3

1. possess self-renewal activity
2. morphologically unrecognizable
3. produce progenitor cells committed to a single cell lineage

Question 4

in an adult, the two best areas of obtaining active bone marrow by aspiration

Answer 4

posterior iliac crest, and sternum

Question 5

normal ratio of myeloid to erythroid precursors in bone marrow (M:E Ratio)

Answer 5

4:1

Question 6

how would you accurately describe hematopoietic growth factor

Answer 6

1. bind to target cell receptor to express activity
2. can stimulate or inhibit cell proliferation
3. may promote or suppress cell death

Question 7

primary site of hematopoiesis in the 3rd month of gestation

Answer 7

liver

Question 8

the mechanism that relays information about tissue oxygen levels to erythropoietin-producing sites is located in the

Answer 8

kidney

Question 9

antigen-independent lymphopoiesis occurs in primary lymphoid tissue located in the

Answer 9

thymus and bone marrow

Question 10

programmed cell death is called

Answer 10

apoptosis

Question 11

in what area of the bone marrow does hematopoiesis take place

Answer 11

cords

Question 12

bone marrow cellularity refers to the ratio of

Answer 12

hematopoietic tissue to adipose tissue

Question 13

interleukins and colony stimulating factors are produced by

Answer 13

monocytes and T lymphocytes

Question 14

what is the approximate total blood volume in an adult?

Answer 14

6 liters of 6,000 milliliters

Question 15

the myeloid progenitor cell can produce cells committed to

Answer 15

Granulocytic, Eryhtrocytic, Monocytic, or megakaryocytic lineages

Question 16

the largest hematopoietic cells in normal bone marrow are

Answer 16

megakaryocytes

Question 17

when evaluating bone marrow aspirate smear, which finding is considered abnormal?

a. a predominance of granulocytes precursors as compared to nucleated red cells
b. detection and stainable iron in macrophages and erythroid precursors with prussian blue
c. an average of three megakaryocytes seen per low power (10x) field
d. the presence of 10% myeloblasts on the cell differential count

Answer 17

d. the presence of 10% myeloblasts on the cell differential count

Question 18

as most blood cell lines mature, which of the following is characteristic?

a. cell diameter increases
b. N:C ratio increases
c. nuclear chromatin becomes less condensed
d. basophilia of the cytoplasm increases

Answer 18

b. N:C ratio increases

Question 19

how would you describe a Thrombopoietin (TPO)?

Answer 19

Hormone produced by the liver that stimulates megakaryopoiesis

Question 20

when the hepatic phase of the fetal life is reactivated in an adult, hematopoiesis can be termed

Answer 20

myeloid metaplasia or extramedullary