Hematopoiesis Flashcards

1
Q

Identify the blood cells in the image

A
  • Erythrocytes (RBC)
  • Granulocytes Neutrophils Eosinophils Basophils
  • Agranulocytes Lymphocytes Monocytes
  • Platelets (cell fragments)
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2
Q

Location of hematopoiesis during development

A
  • Yolk sac – hemangioblasts, progenitors of hematopoietic & endothelial cells
  • Bone marrow – becomes the primary site of hematopoiesis starting at the seventh month of intrauterine life
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3
Q

What is depicted in the image

A

Blood islands

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4
Q

What is depicted

A

Stromal compartment: Stromal cells Adipocytes Endothelial cells Blood sinusoids Macrophages

Hematopoietic compartment: Hematopoietic stem cells Committed precursor cells Maturing cells

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5
Q

Name the stromal compartments

A
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6
Q

Label The image

A
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7
Q

Label the image

A
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8
Q

What is depicted in the image

A

Metamyelocytes

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9
Q

What is depicted in the image

A

Me: Metamyelocytes

PM: Promyelocytes

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10
Q

What is depicted in the image

A

BC: Neutrophilic band cells

EO: Mature Eosinophil

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11
Q

What is depicted in the image

A

Myelocytes

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12
Q

Label the image

A
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13
Q

What is depicted in the image

A
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14
Q

what is depicted in the image

A
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15
Q

Thrombopoietin

A

-produced by the liver and kidneys

– Induced by thrombocytopenia & inflammatory cytokines

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16
Q

What is depicted in the image

A

N. metamyelocyte

17
Q

What is depicted in the image

A
18
Q

What is depicted in the image

A

Megakaryocyte

19
Q

What is depicted in the image

A

Erythroblasts series

20
Q

What is this a section of

A

Bone marrow section

21
Q

Erythropoietin

A

(EPO) produced mainly in the kidneys

– Induced by hypoxia

22
Q

Major generic growth factors:

A
  • GM-CSF (myeloid cells)
  • IL7 (lymphoid cells)
  • IL-3 (granulocyte) Specific growth factors
  • Thrombopoietin
  • Erythropoietin
  • IL-5
23
Q

Committed precursors:

A

CD34+ (used for transplantation)

24
Q

Hematopoietic stem cells:

A

0.05% of total hematopoietic cells (106 – 107 cells)

25
Q

Maturing cells:

A

Erythrocytes lineage

Granulocytes lineage

Platelets