Hematopoiesis Flashcards
Identify the blood cells in the image
- Erythrocytes (RBC)
- Granulocytes Neutrophils Eosinophils Basophils
- Agranulocytes Lymphocytes Monocytes
- Platelets (cell fragments)
Location of hematopoiesis during development
- Yolk sac – hemangioblasts, progenitors of hematopoietic & endothelial cells
- Bone marrow – becomes the primary site of hematopoiesis starting at the seventh month of intrauterine life
What is depicted in the image
Blood islands
What is depicted
Stromal compartment: Stromal cells Adipocytes Endothelial cells Blood sinusoids Macrophages
Hematopoietic compartment: Hematopoietic stem cells Committed precursor cells Maturing cells
Name the stromal compartments
Label The image
Label the image
What is depicted in the image
Metamyelocytes
What is depicted in the image
Me: Metamyelocytes
PM: Promyelocytes
What is depicted in the image
BC: Neutrophilic band cells
EO: Mature Eosinophil
What is depicted in the image
Myelocytes
Label the image
What is depicted in the image
what is depicted in the image
Thrombopoietin
-produced by the liver and kidneys
– Induced by thrombocytopenia & inflammatory cytokines
What is depicted in the image
N. metamyelocyte
What is depicted in the image
What is depicted in the image
Megakaryocyte
What is depicted in the image
Erythroblasts series
What is this a section of
Bone marrow section
Erythropoietin
(EPO) produced mainly in the kidneys
– Induced by hypoxia
Major generic growth factors:
- GM-CSF (myeloid cells)
- IL7 (lymphoid cells)
- IL-3 (granulocyte) Specific growth factors
- Thrombopoietin
- Erythropoietin
- IL-5
Committed precursors:
CD34+ (used for transplantation)
Hematopoietic stem cells:
0.05% of total hematopoietic cells (106 – 107 cells)
Maturing cells:
Erythrocytes lineage
Granulocytes lineage
Platelets
