Hematopoiesis Flashcards
Where are the majority of hematopoiesis done in each trimester?
- Yolk sac
- Liver (small amount in spleen)
- Bone marrow
Where are RBCs made in the bone marrow?
The hematopoietic cell compartment
In the marrow stomal compartment, what is responsible for platelet production?
Endothelial cells
What cell type consumes the nucleus of RBC after they have extruded?
Macrophages
What is the primary form of bone marrow in the medullary cavity of adult bones? Is this active or inactive in erythropoiesis?
Yellow bone marrow, inactive
What are the committed precursors?
Myeloid stem cells (RBC, platelets, monocytes, neutrophils, basophils, eosinophils) and lymphoid stem cells (B and T cells)
What interleukin is used for myeloid stem cells?
SCF then IL3
What IL are used for lymphoid stem cells?
1 and 4
What is used to treat neutropenia after chemotherapy or bone marrow transplant?
G-CSF (granulocyte colony-stimulating factor)
Where are EPO and TPO primarily produced? What do they produce?
EPO - kidney and stimulates the production of RBC
TPO - produced in liver and stimulates an increase in megakaryocytes and platelets
What is the role of RBC and platelets?
RBC - pick up O2 in lungs and drop in tissue; pick up CO2 in tissues and drop in lungs
Platelets - secrete vasoconstrictors and form a temporary plug
Polychromatophilic erythroblast show what characteristic?
3rd stage of 5
checkerboard pattern nucleus
The first stage after the nucleus has been extruded?
Polychromatophilic erthrocyte (reticulocyte)
Reticulocytes shave to be stained with _______________ which causes the ______________ to clump
Supravital stain, ribosomes
Basophillic erythroblasts are different in that they have coarse _____________ and they have a _______________ nucleus:cytoplasm ratio
Chromatin, decreased
