Hematopoiesis

Question 1

• Pre natal (0-3 months)? 2-7 months?
• Post natal? Child? Adult?
• Myeloid cells? (4)
• Lymphoid cells?
• Stem cell: can give rise to? pluripotent? multipotent?
• Progenitor: Committed stem cell to?
• Precursor: Recognizable maturing cell? Renewal?
• Self renewal prevents?
• Majority of hematopoietic cells?

Answer 1

• yolk sac; Liver/spleen
• Bone marrow; axial; vertebrae, pelvis, sternum, ribs
• Granulocytes, RBCs, ptts, mono
• B, T, NK
• Any myeloid; M or L lineage; mother of all
• One or two lineages
• Yes, No
• Bone marrow depletion
• Precursor or mature

Question 2

• Maturation dictated by?
• Differentiation?
• Hemato GF’s? (5)
• Myoblast goes to?
• Monocyte goes to?
• Large granular?
• Small?
• Cellular bone marrow 50-50%?
• Decreases with?
• M:E ratio?

Answer 2

• gene expression; protein accumulation
• Genes on or off
• EPO; IL3; G-CSF (Inc n’s), GMSH (inc. macs); MCSF
• B,E,N and mono
• Macro/denrdritic
• NK
• TH and B
• Hematopoeitcally active and bone
• Age
• Granulo: Erythro = 3:1