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[PHY2] 3rd Shift > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

VR

  1. Age in Years
  2. Sites of Hematopoiesis
A

B: Increase in 1 will Decrease 2

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2
Q

QC

Lifespan of RBC in:
1. Normal Individual
2. Individual w/ Hereditary Spherocytosis

A

A: 1 > 2

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3
Q

VR

  1. Number of CFU-E
  2. Number of Platelets/cu mm of blood
A

C: Increase in 1 will not affect 2

Should be CFU-M

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4
Q

VR

  1. Maturity of RBCs
  2. Size
A

B: Increase in1 will Decrease 2

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5
Q

VR

  1. History of Smoking
  2. Hematocrit
A

A: Increase in 1 will Increase 2

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6
Q

VR

  1. Degree of Anemia
  2. Cardiac Output
A

A: Increase in 1 will Increase 2

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7
Q

VR

  1. Plasma Epinephrine Level
  2. Erythropoietin Secretion
A

A: Increase in 1 will Increase 2

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8
Q

QC

Erythropoietin Production in:
1. Liver
2. Kidney

A

B: A < B

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9
Q

VR

  1. Maturity of RBC
  2. Presence of Nucleus
A

B: Increase in 1 will Decrease 2

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10
Q

QC

Size of RBC if blood loss is:
1. Acute
2. Chronic

A

A: A > B

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11
Q

QC

Site of Hematopoiesis at 5 months age of Gestation
1. Liver
2. Yolk Sac

A

A: A > B

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12
Q

VR

  1. Number of RBC per cu mm of Blood
  2. Blood Viscosity
A

A: Increase in 1 will Increase 2

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13
Q

VR

  1. PaO2
  2. Erythropoietin Secretion
A

B: Increase in 1 will Decrease 2

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14
Q

VR

Amount absorbed in the Ileum
1. Vitamin B12
2. Folic Acid

A

A: A > B

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15
Q

Red blood cell count in cu mm
1. Male
2. Female

A

A: 1 > 2

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16
Q

Arterial O2 Content
A. O2 in RBC
B. O2 in Plasma

A

A: A > B

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17
Q

Iron form for easier absorption
A. Ferrous
B. Ferritin

A

A: A > B
Ferrtin is for storage

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18
Q

Site of Hematopoiesis in fetus at the last trimester
1. Yolksac
2. Bone marrow of all bones

A

B: A < B

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19
Q

Site of Hematopoiesis in 5 year olds
1. Bone marrow of flat bones
2. Bone marrow of prox tibia & humerus

A

B: A < B

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20
Q

A. CFU-GM
B. Lymphocytes

A

C: A will not affect B

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21
Q

A. Colony Forming Blastocytes
B. Platelets

A

A: Increase in A will Increase B

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22
Q

A. CFU-E
B. RBC

A

A: Increase in A will Increase B

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23
Q

Growth Inducer
A. Infection
B. Hypoxia

Differentiation Inducer
A. Infection
B. Hypoxia

A
  1. B: A < B - Inc Production of RBC
  2. A: A > B Inc conversion to WBC
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24
Q
  1. First Cell in the RBC series
  2. Cells start filling up w hemoglobin
  3. Cells can pass from bone marrow to capillaries via diapedesis
A
  1. Proerythroblast
  2. Polychromatophil Erythroblast
  3. Reticulocytes
25
Q
  1. EPO
  2. RBC
A

A: Increase in 1 will Increase 2

26
Q

EPO Production
1. Kidneys
2. Liver

A

A: 1 > 2

27
Q
  1. Renal Failure
  2. RBC Circulation
A

B: Increase in 1 will Decrease 2

28
Q

Most essential regulator of RBC Production

A

Tissue Oxygenation

29
Q
  1. Hypoxia
  2. EPO Production
A

A: Increase in 1 will Increase 2

30
Q
  1. O2
  2. EPO production
A

B: Increase in A will Decrease 2

31
Q
  1. Pulmonary Disease
  2. RBC
A

A: Increase in A will Increase B

32
Q
  1. Altitude
  2. RBC
A

A: Increase in 1 will Decrease 2

33
Q
  1. CHF
  2. RBC
A

A: Increase in 1 will Decrease 2

34
Q

RBC Production
1. Liver Disease
2. Lung Disease

A

B: 1 < 2

Liver Disease => Dec EPO => Dec RBC; Lung Disease => Inc EPO

35
Q

RBC Production
1. Kidney Disease
2. Liver Disease

A

B: 1 < 2

Kidneys main producer of EPO: Pathology => more significant dec in EPO

36
Q
  1. Dehydration
  2. Hematocrit
A

A: Increase in 1 will decrease 2

37
Q
  1. Anemia
  2. Hematocrit
A

A: Increase in 1 will Increase 2

38
Q
  1. Epi/NE
  2. RBC Prod
A

A: Increase in 1 will Increase 2

39
Q
  1. HIF-1
  2. EPO Prod
A

A: Increase in 1 will increase 2

40
Q
  1. B12 Absorption
  2. Maturation of RBC
A

A: Increase in 1 will Increase 2

41
Q
  1. B12 Absorption
  2. Size of RBC
A

B: Increase in 1 will Decrease 2

42
Q
  1. Folic Acid Deficiency
  2. Size of RBC
A

A: Increase in 1 will Increase 2

43
Q
  1. Antiparietal Antibodies
  2. Size of RBC
A

A: Increase in 1 will Increase 2
Antiparietal => Dec B12 Absorption => Megaloblastic/ pernicious Anemia

44
Q
  1. Intrinsic Factors
  2. FUnctional RBC
A

A: Increase in 1 will Increase 2

45
Q
  1. Parietal Cell Secretions
  2. Functional RBC
A

A: Increase in 1 will Increase 2

46
Q

Size of RBC
1. Antiparietal antibodies
2. IF

A

A: 1 > 2

larger rbc = not functional

47
Q

Which nutrients are absorbed in:
1. Jejunum
2. Ileum
3. Duodenum

A
  1. Folic acid
  2. Vit B12
  3. Iron
48
Q

In 1 RBC, how many of the ff are there:
1. Hemoglobin Molecule
2. a chains
3. b chains
4. Heme
5. Globin
6. Protoporphyrin IX
7. Iron
8. Pyrrole
9. succinyl CoA
10. Glycine
11. O2

A
  1. 1
  2. 2
  3. 2
  4. 4
  5. 4
  6. 4
  7. 4
  8. 16
  9. 32
  10. 32
  11. 4
49
Q

% of Iron in the body is found in
1. bound to hemoglobin
2. Stored in RES

  1. Myoglobin
  2. Transferrin
A

A: 1 > 2

A: 1 > 2

50
Q

Storage form if Apoferritin are all used up
1. Ferritin
2. Hemosiderin

A

B: 1 < 2

51
Q

Storage for of Fe bounded to Apoferritin
1. Ferritin
2. Hemosiderin

A

A: 1 > 2

52
Q
  1. RBC Destruction
  2. B1
A

A: Increase in 1 will Increase 2

53
Q

RBC Size
1. Peptic Ulcer
2. Gastrectomy

A

B: 1 < 2

Peptic Ulcer: Chronic Blood Loss = Smol
Gastrectomy: Def in B12 = Big

54
Q

Bone Marrow Dysfunction
1. Megaloblastic anemia
2. Aplastic anemia

A

B: 1 < 2

55
Q

RBC Destruction if
1. Biconcave shape
2. Spherical shape

A

B: 1 < 2

56
Q
  1. VR
    A. Anemia
    B. Vasodilation
  2. VR
    A. Anemia
    B. Venous Return
  3. VR
    A. Anemia
    B. Viscosity
  4. VR
    A. Anemia
    B. Resistance
  5. VR
    A. Anemia
    B. Hematocrit
A
  1. A: Increase Increase
  2. A: Increase Increase
  3. B: Increase Decrease
  4. B: Increase Decrease
  5. B: Increase Decrease
57
Q

Identify the Pathologies
1. Abnormalities in RBC structure
2. Abnormalities in Hb

A
  1. Hereditary Spherocytosis
  2. Sickle Cell Anemia
58
Q

Hematocrit in
1. Anemia
2. Polycythemia

Blood volume in
1. Anemia
2. Polycythemia

Risk for Stroke
1. Anemia
2. Polycythemia

End Stage Renal Disease causes
1. Anemia
2. Polycythemia

A

B: 1 < 2

B: 1 < 2

B: 1 < 2

A: 1 > 2

[PHY2] 3rd Shift (2 decks)

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