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[PHY2] 3rd Shift > Hematopoiesis > Flashcards

Hematopoiesis Flashcards

1
Q

VR

  1. Age in Years
  2. Sites of Hematopoiesis
A

B: Increase in 1 will Decrease 2

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2
Q

QC

Lifespan of RBC in:
1. Normal Individual
2. Individual w/ Hereditary Spherocytosis

A

A: 1 > 2

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3
Q

VR

  1. Number of CFU-E
  2. Number of Platelets/cu mm of blood
A

C: Increase in 1 will not affect 2

Should be CFU-M

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4
Q

VR

  1. Maturity of RBCs
  2. Size
A

B: Increase in1 will Decrease 2

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5
Q

VR

  1. History of Smoking
  2. Hematocrit
A

A: Increase in 1 will Increase 2

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6
Q

VR

  1. Degree of Anemia
  2. Cardiac Output
A

A: Increase in 1 will Increase 2

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7
Q

VR

  1. Plasma Epinephrine Level
  2. Erythropoietin Secretion
A

A: Increase in 1 will Increase 2

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8
Q

QC

Erythropoietin Production in:
1. Liver
2. Kidney

A

B: A < B

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9
Q

VR

  1. Maturity of RBC
  2. Presence of Nucleus
A

B: Increase in 1 will Decrease 2

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10
Q

QC

Size of RBC if blood loss is:
1. Acute
2. Chronic

A

A: A > B

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11
Q

QC

Site of Hematopoiesis at 5 months age of Gestation
1. Liver
2. Yolk Sac

A

A: A > B

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12
Q

VR

  1. Number of RBC per cu mm of Blood
  2. Blood Viscosity
A

A: Increase in 1 will Increase 2

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13
Q

VR

  1. PaO2
  2. Erythropoietin Secretion
A

B: Increase in 1 will Decrease 2

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14
Q

VR

Amount absorbed in the Ileum
1. Vitamin B12
2. Folic Acid

A

A: A > B

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15
Q

Red blood cell count in cu mm
1. Male
2. Female

A

A: 1 > 2

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16
Q

Arterial O2 Content
A. O2 in RBC
B. O2 in Plasma

A

A: A > B

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17
Q

Iron form for easier absorption
A. Ferrous
B. Ferritin

A

A: A > B
Ferrtin is for storage

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18
Q

Site of Hematopoiesis in fetus at the last trimester
1. Yolksac
2. Bone marrow of all bones

A

B: A < B

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19
Q

Site of Hematopoiesis in 5 year olds
1. Bone marrow of flat bones
2. Bone marrow of prox tibia & humerus

A

B: A < B

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20
Q

A. CFU-GM
B. Lymphocytes

A

C: A will not affect B

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21
Q

A. Colony Forming Blastocytes
B. Platelets

A

A: Increase in A will Increase B

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22
Q

A. CFU-E
B. RBC

A

A: Increase in A will Increase B

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23
Q

Growth Inducer
A. Infection
B. Hypoxia

Differentiation Inducer
A. Infection
B. Hypoxia

A
  1. B: A < B - Inc Production of RBC
  2. A: A > B Inc conversion to WBC
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24
Q
  1. First Cell in the RBC series
  2. Cells start filling up w hemoglobin
  3. Cells can pass from bone marrow to capillaries via diapedesis
A
  1. Proerythroblast
  2. Polychromatophil Erythroblast
  3. Reticulocytes
25
1. EPO 2. RBC
**A:** Increase in 1 will Increase 2
26
**EPO Production** 1. Kidneys 2. Liver
**A:** 1 > 2
27
1. Renal Failure 2. RBC Circulation
**B:** Increase in 1 will Decrease 2
28
Most essential regulator of RBC Production
Tissue Oxygenation
29
1. Hypoxia 2. EPO Production
**A:** Increase in 1 will Increase 2
30
1. O2 2. EPO production
**B:** Increase in A will Decrease 2
31
1. Pulmonary Disease 2. RBC
**A:** Increase in A will Increase B
32
1. Altitude 2. RBC
**A:** Increase in 1 will Decrease 2
33
1. CHF 2. RBC
**A:** Increase in 1 will Decrease 2
34
RBC Production 1. Liver Disease 2. Lung Disease
**B:** 1 < 2 | Liver Disease => Dec EPO => Dec RBC; Lung Disease => Inc EPO
35
RBC Production 1. Kidney Disease 2. Liver Disease
**B:** 1 < 2 | Kidneys main producer of EPO: Pathology => more significant dec in EPO
36
1. Dehydration 2. Hematocrit
**A:** Increase in 1 will decrease 2
37
1. Anemia 2. Hematocrit
**A:** Increase in 1 will Increase 2
38
1. Epi/NE 2. RBC Prod
**A:** Increase in 1 will Increase 2
39
1. HIF-1 2. EPO Prod
**A:** Increase in 1 will increase 2
40
1. B12 Absorption 2. Maturation of RBC
**A:** Increase in 1 will Increase 2
41
1. B12 Absorption 2. Size of RBC
**B:** Increase in 1 will Decrease 2
42
1. Folic Acid Deficiency 2. Size of RBC
**A:** Increase in 1 will Increase 2
43
1. Antiparietal Antibodies 2. Size of RBC
**A:** Increase in 1 will Increase 2 Antiparietal => Dec B12 Absorption => Megaloblastic/ pernicious Anemia
44
1. Intrinsic Factors 2. FUnctional RBC
**A:** Increase in 1 will Increase 2
45
1. Parietal Cell Secretions 2. Functional RBC
**A:** Increase in 1 will Increase 2
46
Size of RBC 1. Antiparietal antibodies 2. IF
**A:** 1 > 2 larger rbc = not functional
47
Which nutrients are absorbed in: 1. Jejunum 2. Ileum 3. Duodenum
1. Folic acid 2. Vit B12 3. Iron
48
In 1 RBC, how many of the ff are there: 1. Hemoglobin Molecule 2. a chains 3. b chains 4. Heme 5. Globin 6. Protoporphyrin IX 7. Iron 8. Pyrrole 9. succinyl CoA 10. Glycine 11. O2
1. 1 2. 2 3. 2 4. 4 5. 4 6. 4 7. 4 8. 16 9. 32 10. 32 11. 4
49
% of Iron in the body is found in 1. bound to hemoglobin 2. Stored in RES 1. Myoglobin 2. Transferrin
**A:** 1 > 2 **A:** 1 > 2
50
Storage form if Apoferritin are all used up 1. Ferritin 2. Hemosiderin
**B:** 1 < 2
51
Storage for of Fe bounded to Apoferritin 1. Ferritin 2. Hemosiderin
**A:** 1 > 2
52
1. RBC Destruction 2. B1
**A:** Increase in 1 will Increase 2
53
RBC Size 1. Peptic Ulcer 2. Gastrectomy
**B:** 1 < 2 Peptic Ulcer: Chronic Blood Loss = Smol Gastrectomy: Def in B12 = Big
54
Bone Marrow Dysfunction 1. Megaloblastic anemia 2. Aplastic anemia
**B:** 1 < 2
55
RBC Destruction if 1. Biconcave shape 2. Spherical shape
**B:** 1 < 2
56
1. **VR** A. Anemia B. Vasodilation 2. **VR** A. Anemia B. Venous Return 3. **VR** A. Anemia B. Viscosity 4. **VR** A. Anemia B. Resistance 5. **VR** A. Anemia B. Hematocrit
1. **A:** Increase Increase 2. **A:** Increase Increase 3. **B:** Increase Decrease 4. **B:** Increase Decrease 5. **B:** Increase Decrease
57
Identify the Pathologies 1. Abnormalities in RBC structure 2. Abnormalities in Hb
1. Hereditary Spherocytosis 2. Sickle Cell Anemia
58
Hematocrit in 1. Anemia 2. Polycythemia Blood volume in 1. Anemia 2. Polycythemia Risk for Stroke 1. Anemia 2. Polycythemia End Stage Renal Disease causes 1. Anemia 2. Polycythemia
**B:** 1 < 2 **B:** 1 < 2 **B:** 1 < 2 **A:** 1 > 2

[PHY2] 3rd Shift (2 decks)

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