Hematology - coagulation disorders Flashcards
1
Q
Hemophilia A is a deficiency in which clotting factor?
A
VIII
2
Q
Treatment of hemophilia A
A
- Cryoprecipitate (factor VIII)
- Desmopressin (for mild cases) increases factor VIII and vWF
3
Q
Hemophilia B is a deficiency in which clotting factor?
A
IX
4
Q
Treatment of hemophilia B
A
FFP or purified factor IX
5
Q
What does vitamin K do in the clotting cascade?
A
functional activation of clotting factors: II, VII, IX, X
6
Q
Why is vitamin K given to newborns?
A
To help activate clotting factors so that they don’t bleed spontaneously
7
Q
Functions of vWF
A
- carries VIII in plasma
- increase platelet adhesion
- affects platelet function
8
Q
Treatment of vWF disease
A
- Humate-P (factor VIII concentrate complexed to vWF)
- desmopressin
9
Q
Laboratory assessment of bleeding disorders
A
- PT (prothrombin time)/INR for extrinsic pathway
- PTT (partial thromboplastin time) for intrinsic pathway
